Chhabra Ravneet, Saha Aishwarya, Chamani Ashkon, Schneider Nicole, Shah Riya, Nanjundan Meera
Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL 33620, USA.
Pharmaceuticals (Basel). 2020 Sep 25;13(10):275. doi: 10.3390/ph13100275.
Iron is an essential element required to support the health of organisms. This element is critical for regulating the activities of cellular enzymes including those involved in cellular metabolism and DNA replication. Mechanisms that underlie the tight control of iron levels are crucial in mediating the interaction between microorganisms and their host and hence, the spread of infection. Microorganisms including viruses, bacteria, and fungi have differing iron acquisition/utilization mechanisms to support their ability to acquire/use iron (e.g., from free iron and heme). These pathways of iron uptake are associated with promoting their growth and virulence and consequently, their pathogenicity. Thus, controlling microorganismal survival by limiting iron availability may prove feasible through the use of agents targeting their iron uptake pathways and/or use of iron chelators as a means to hinder development of infections. This review will serve to assimilate findings regarding iron and the pathogenicity of specific microorganisms, and furthermore, find whether treating infections mediated by such organisms via iron chelation approaches may have potential clinical benefit.
铁是维持生物体健康所需的必需元素。该元素对于调节细胞酶的活性至关重要，这些酶包括参与细胞代谢和DNA复制的酶。严格控制铁水平的机制对于介导微生物与其宿主之间的相互作用以及感染的传播至关重要。包括病毒、细菌和真菌在内的微生物具有不同的铁获取/利用机制，以支持它们获取/利用铁的能力（例如，从游离铁和血红素中获取）。这些铁摄取途径与促进它们的生长和毒力相关，进而与它们的致病性相关。因此，通过限制铁的可用性来控制微生物的存活可能通过使用针对其铁摄取途径的药物和/或使用铁螯合剂作为阻碍感染发展的手段来实现。本综述将有助于汇总关于铁与特定微生物致病性的研究结果，此外，还将探究通过铁螯合方法治疗由此类微生物介导的感染是否可能具有潜在的临床益处。
