Heukamp Nils Jannik, Banaschewski Tobias, Bokde Arun L W, Desrivières Sylvane, Grigis Antoine, Garavan Hugh, Gowland Penny, Heinz Andreas, Kandić Mina, Brühl Rüdiger, Martinot Jean-Luc, Paillère Martinot Marie-Laure, Artiges Eric, Papadopoulos Orfanos Dimitri, Lemaitre Herve, Löffler Martin, Poustka Luise, Hohmann Sarah, Millenet Sabina, Fröhner Juliane H, Smolka Michael N, Usai Katrin, Vaidya Nilakshi, Walter Henrik, Whelan Robert, Schumann Gunter, Flor Herta, Nees Frauke
Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
iScience. 2024 Jan 17;27(2):108954. doi: 10.1016/j.isci.2024.108954. eCollection 2024 Feb 16.
During late adolescence, the brain undergoes ontogenic organization altering subcortical-cortical circuitry. This includes regions implicated in pain chronicity, and thus alterations in the adolescent ontogenic organization could predispose to pain chronicity in adulthood - however, evidence is lacking. Using resting-state functional magnetic resonance imaging from a large European longitudinal adolescent cohort and an adult cohort with and without chronic pain, we examined links between painful symptoms and brain connectivity. During late adolescence, thalamo-, caudate-, and red nucleus-cortical connectivity were positively and subthalamo-cortical connectivity negatively associated with painful symptoms. Thalamo-cortical connectivity, but also subthalamo-cortical connectivity, was increased in adults with chronic pain compared to healthy controls. Our results indicate a shared basis in basothalamo-cortical circuitries between adolescent painful symptomatology and adult pain chronicity, with the subthalamic pathway being differentially involved, potentially due to a hyperconnected thalamo-cortical pathway in chronic pain and ontogeny-driven organization. This can inform neuromodulation-based prevention and early intervention.
在青春期后期，大脑经历个体发育组织过程，改变皮层下 - 皮层神经回路。这包括与疼痛慢性化相关的区域，因此青少年个体发育组织的改变可能使成年后易患疼痛慢性化——然而，目前缺乏相关证据。我们利用来自一个大型欧洲纵向青少年队列以及一个有或没有慢性疼痛的成年队列的静息态功能磁共振成像，研究了疼痛症状与大脑连通性之间的联系。在青春期后期，丘脑、尾状核和红核与皮层的连通性与疼痛症状呈正相关，而底丘脑与皮层的连通性与疼痛症状呈负相关。与健康对照组相比，患有慢性疼痛的成年人丘脑与皮层的连通性以及底丘脑与皮层的连通性均有所增加。我们的结果表明，青少年疼痛症状学和成人疼痛慢性化在基底丘脑 - 皮层回路中存在共同基础，底丘脑通路的参与情况有所不同，这可能是由于慢性疼痛中丘脑 - 皮层通路过度连通以及个体发育驱动的组织所致。这可为基于神经调节的预防和早期干预提供依据。
