Ligan Caryl, Ma Xin-Hua, Zhao Shu-Li, Zhao Wei
General Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University Nanjing, Jiangsu, China.
Department of Pathology, Nanjing First Hospital, Nanjing Medical University Nanjing, Jiangsu, China.
Am J Cancer Res. 2024 Jan 15;14(1):1-15. doi: 10.62347/EZST5505. eCollection 2024.
Mast cells (MCs) have emerged as pivotal contributors to both the defensive immune response and immunomodulation. They also exhibit regulatory functions in modulating pathological processes across various allergic diseases. The impact of MC presence within tumor tissues has garnered considerable attention, yielding conflicting findings. While some studies propose that MCs within tumor tissues promote tumor initiation and progression, others advocate an opposing perspective. Notably, evidence emphasizes the dual role of MCs in cancer, both as promoters and suppressors, is crucial for optimizing cancer treatment strategies. These conflicting viewpoints have generated substantial controversy, underscoring the need for a comprehensive understanding of MC's role in tumor immune responses.
肥大细胞（MCs）已成为防御性免疫反应和免疫调节的关键贡献者。它们在调节各种过敏性疾病的病理过程中也表现出调节功能。肿瘤组织中MCs的存在所产生的影响已引起了相当多的关注，结果相互矛盾。虽然一些研究表明肿瘤组织中的MCs促进肿瘤的发生和进展，但另一些研究则持相反观点。值得注意的是，有证据强调MCs在癌症中作为促进者和抑制者的双重作用，这对于优化癌症治疗策略至关重要。这些相互矛盾的观点引发了大量争议，凸显了全面了解MCs在肿瘤免疫反应中作用的必要性。
