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克罗恩病伴或不伴焦虑和抑郁患者杏仁核亚区功能连接异常。

Abnormal Amygdala Subregion Functional Connectivity in Patients with Crohn's Disease with or without Anxiety and Depression.

机构信息

Department of Radiology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China.

Graduate College, Dalian Medical University, Dalian, China.

出版信息

Behav Neurol. 2024 Jan 30;2024:1551807. doi: 10.1155/2024/1551807. eCollection 2024.

DOI:10.1155/2024/1551807
PMID:38323301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10846920/
Abstract

OBJECTIVE

The aim of this study was to explore the resting-state functional connectivity (rsFC) of amygdala subregions in healthy controls (HCs) and in patients with Crohn's disease (CD) both with and without anxiety or depression.

MATERIALS AND METHODS

A total of 33 patients with CD and with anxiety or depression (CDad group), 31 patients with CD but without anxiety or depression (CDnad group), and 29 age-, sex-, and education level-matched HCs underwent functional magnetic resonance imaging. rsFC analysis was used to analyze the FC between the amygdala subregions and other areas of the brain.

RESULTS

Compared with the HC group, the CDad group demonstrated decreased rsFC between the right laterobasal subregion and the left hippocampus ( < .001) and right middle frontal gyrus ( < .001) and between the left superficial subregion and the left insula ( < .001). Compared with the HC group, the CDnad group demonstrated decreased rsFC between the left centromedial subregion and the left insula ( < .001). Compared with the CDnad group, the CDad group demonstrated decreased rsFC between the left centromedial subregion and the right precuneus ( < .001) and postcentral gyrus ( < .001), between the right laterobasal subregion and the left hippocampus ( < .001), and between the left superficial subregion and the right middle frontal gyrus ( < .001).

CONCLUSIONS

There are significant FC changes in the amygdala subregions in patients with CD. These changes may be related to the disease itself or to the symptoms of anxiety and depression.

摘要

目的

本研究旨在探讨健康对照者（HCs）和伴有或不伴有焦虑或抑郁的克罗恩病（CD）患者的杏仁核亚区静息态功能连接（rsFC）。

材料和方法

共纳入 33 例伴有焦虑或抑郁的 CD 患者（CDad 组）、31 例不伴有焦虑或抑郁的 CD 患者（CDnad 组）和 29 名年龄、性别和教育程度匹配的 HCs 进行功能磁共振成像检查。采用 rsFC 分析方法分析杏仁核亚区与大脑其他区域之间的 FC。

结果

与 HC 组相比，CDad 组右侧基底外侧亚区与左侧海马（ <.001）和右侧额中回（ <.001）之间以及左侧浅层亚区与左侧岛叶（ <.001）之间的 rsFC 降低。与 HC 组相比，CDnad 组左侧中央内侧亚区与左侧岛叶（ <.001）之间的 rsFC 降低。与 CDnad 组相比，CDad 组左侧中央内侧亚区与右侧楔前叶（ <.001）和中央后回（ <.001）之间、右侧基底外侧亚区与左侧海马之间（ <.001）以及左侧浅层亚区与右侧额中回（ <.001）之间的 rsFC 降低。

结论

CD 患者杏仁核亚区存在明显的 FC 变化，这些变化可能与疾病本身或焦虑和抑郁的症状有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4765/10846920/7fd60545a7ab/BN2024-1551807.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4765/10846920/258e05354e4c/BN2024-1551807.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4765/10846920/2993eb652af5/BN2024-1551807.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4765/10846920/6442a7e15258/BN2024-1551807.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4765/10846920/7fd60545a7ab/BN2024-1551807.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4765/10846920/258e05354e4c/BN2024-1551807.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4765/10846920/2993eb652af5/BN2024-1551807.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4765/10846920/6442a7e15258/BN2024-1551807.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4765/10846920/7fd60545a7ab/BN2024-1551807.004.jpg

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