The College of Pediatrics, Chongqing Medical University, Chongqing, China.
The Second Medicine College, Chongqing Medical University, Chongqing, China.
Int J Cancer. 2024 Jun 1;154(11):1948-1954. doi: 10.1002/ijc.34876. Epub 2024 Feb 7.
Endometriosis has been reported in epidemiological studies to be associated with certain types of cancer. However, the presence of reverse causality and residual confounding due to common risk factors introduces uncertainty regarding the extent to which endometriosis itself contributes to the development of cancer. We performed the Mendelian randomization (MR) to investigate the causal associations between endometriosis and 34 different types of cancers. The results of the inverse-variance-weighted (IVW) model suggested that genetic predisposition to endometriosis was causally associated with an increased risk for ovarian cancer (OR = 3.2913; p-value = .0320). The genetic liabilities to endometriosis had causal associations with the decreased risk for skin cancer (OR = 0.9973; p-value = .0219), hematological cancer (OR = 0.9953; p-value = .0175) and ER- breast cancer (OR = 0.6960; p-value = .0381). The causal association of the above combinations were robust by test of heterogeneity and pleiotropy. Together, our study suggests that endometriosis had causal effect on cancer risk.
子宫内膜异位症在流行病学研究中被报道与某些类型的癌症有关。然而，由于共同的风险因素存在反向因果关系和残余混杂，因此子宫内膜异位症本身对癌症发展的影响程度存在不确定性。我们进行了孟德尔随机化 (MR) 来研究子宫内膜异位症与 34 种不同类型癌症之间的因果关系。逆方差加权 (IVW) 模型的结果表明，子宫内膜异位症的遗传易感性与卵巢癌的风险增加有关（OR=3.2913；p 值=.0320）。子宫内膜异位症的遗传倾向与皮肤癌（OR=0.9973；p 值=.0219）、血液癌（OR=0.9953；p 值=.0175）和 ER-乳腺癌（OR=0.6960；p 值=.0381）的风险降低有关。通过异质性和多效性检验，上述组合的因果关系具有稳健性。综上所述，我们的研究表明子宫内膜异位症对癌症风险有因果影响。
