Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Front Endocrinol (Lausanne). 2024 Feb 29;15:1271351. doi: 10.3389/fendo.2024.1271351. eCollection 2024.
A potential association between periodontitis and endometriosis has been indicated in previous observational studies. Nevertheless, the causal link between these two disorders has not been clarified.
Based on publicly available genome-wide association study (GWAS) summary datasets, we conducted a bidirectional Mendelian randomization (MR) study to investigate the relationship between periodontitis and endometriosis and its subtypes. Single nucleotide polymorphisms (SNPs) strongly associated with candidate exposures at the genome-wide significance level ( < 5 × 10) were selected as instrumental variables (IVs). The inverse variance-weighted regression (IVW) was performed to estimate the causal effect of periodontitis on endometriosis. We further conducted two sensitivity analyses, MR-Egger and weighted median, to test the validity of our findings. The main results were replicated via data from the UK Biobank. Finally, a reverse MR analysis was performed to evaluate the possibility of reverse causality.
The IVW method suggested that periodontitis was positively associated with endometriosis of the pelvic peritoneum (OR = 1.079, 95% CI = 1.016 to 1.146, = 0.014). No causal association was indicated between periodontitis and other subtypes of endometriosis. In reversed analyses, no causal association between endometriosis or its subtypes and periodontitis was found.
Our study provided genetic evidence on the causal relationship between periodontitis and endometriosis of the pelvic peritoneum. More studies are necessary to explore the underlying mechanisms.
先前的观察性研究表明，牙周炎和子宫内膜异位症之间可能存在关联。然而，这两种疾病之间的因果关系尚未阐明。
基于公开的全基因组关联研究（GWAS）汇总数据集，我们进行了一项双向孟德尔随机化（MR）研究，以调查牙周炎和子宫内膜异位症及其亚型之间的关系。选择与候选暴露物具有全基因组显著关联（<5×10）的单核苷酸多态性（SNP）作为工具变量（IV）。采用逆方差加权回归（IVW）估计牙周炎对子宫内膜异位症的因果效应。我们进一步进行了 MR-Egger 和加权中位数两种敏感性分析，以检验我们研究结果的有效性。主要结果通过英国生物库的数据进行了复制。最后，进行了反向 MR 分析，以评估反向因果关系的可能性。
IVW 方法表明，牙周炎与盆腔腹膜子宫内膜异位症呈正相关（OR=1.079，95%CI=1.016 至 1.146，P=0.014）。牙周炎与子宫内膜异位症的其他亚型之间没有因果关联。在反向分析中，也没有发现子宫内膜异位症或其亚型与牙周炎之间存在因果关系。
本研究提供了遗传证据，表明牙周炎与盆腔腹膜子宫内膜异位症之间存在因果关系。需要进一步的研究来探索潜在的机制。
