Department of Adult Health Nursing, College of Health Science, School of Nursing, Aksum University, Aksum, Ethiopia.
Department of Maternity and Neonatal Nursing, College of Health Science, School of Nursing, Aksum University, Aksum, Ethiopia.
Int Health. 2024 Sep 5;16(5):499-511. doi: 10.1093/inthealth/ihae011.
Chronic obstructive pulmonary disease (COPD) is a common lung disease that causes restricted airflow and breathing problems. Globally, COPD is the third leading cause of death and low- and middle-income countries account for the majority of these deaths. There is limited information on COPD's prevalence in East Africa. Thus the purpose of this systematic review and meta-analysis is to estimate the pooled prevalence of COPD in East Africa.A computerized systematic search using multiple databases was performed in search of relevant English articles from the inception of the databases to August 2023. All the authors independently extracted the data. R and RStudio software were used for statistical analysis. Forest plots and tables were used to represent the data. The statistical heterogeneity was evaluated using I2 statistics. There was heterogeneity between the included articles. Therefore, a meta-analysis of random effects models was used to estimate the overall pooled prevalence of COPD in East Africa. A funnel plot test was used to examine possible publication bias.The database search produced 512 papers. After checking for inclusion and exclusion criteria, 43 full-text observational studies with 68 553 total participants were found suitable for the review. The overall pooled prevalence of COPD in East Africa was 13.322%. The subgroup analysis found the COPD pooled prevalence in the different countries was 18.994%, 7%, 15.745%, 9.032%, 15.026% and 11.266% in Ethiopia, Uganda, Tanzania, Malawi, Sudan, and Kenya, respectively. Additionally, the subgroup analysis of COPD by study setting among community-based studies was 12.132% and 13.575% for hospital-based studies.According to the study's findings, approximately one of every seven individuals in East Africa has COPD, indicating a notably high prevalence of the disease. Thus governments and other stakeholders working on non-communicable disease control should place an emphasis on preventive measures to minimize the burden of COPD.
慢性阻塞性肺疾病（COPD）是一种常见的肺部疾病，会导致气流受限和呼吸问题。在全球范围内，COPD 是第三大致死原因，而中低收入国家占这些死亡人数的大多数。东非地区 COPD 的流行情况信息有限。因此，本系统评价和荟萃分析的目的是估计东非地区 COPD 的患病率。使用多个数据库进行了计算机系统检索，以搜索从数据库创建到 2023 年 8 月期间发表的相关英文文章。所有作者均独立提取数据。使用 R 和 RStudio 软件进行统计分析。使用森林图和表格表示数据。使用 I2 统计量评估统计异质性。纳入的文章之间存在异质性。因此，使用随机效应模型的荟萃分析来估计东非地区 COPD 的总体患病率。使用漏斗图检验来检查可能存在的发表偏倚。数据库检索产生了 512 篇论文。在检查纳入和排除标准后，发现了 43 项具有 68553 名总参与者的观察性研究全文适合进行综述。东非地区 COPD 的总体患病率为 13.322%。亚组分析发现，东非不同国家的 COPD 患病率分别为埃塞俄比亚 18.994%、乌干达 7%、坦桑尼亚 15.745%、马拉维 9.032%、苏丹 15.026%和肯尼亚 11.266%。此外，社区为基础研究中 COPD 的亚组分析显示，医院为基础研究的 COPD 患病率为 12.132%和 13.575%。根据研究结果，东非地区大约每七个人中就有一人患有 COPD，表明该疾病的患病率相当高。因此，致力于非传染性疾病控制的政府和其他利益相关者应重视预防措施，以尽量减少 COPD 的负担。
