美国南亚裔男性中总胆红素与 2 型糖尿病呈负相关，但女性中并非如此。
Inverse association between total bilirubin and type 2 diabetes in U.S. South Asian males but not females.
机构信息
Center for Pharmacoepidemiology and Treatment Sciences, Rutgers Institute for Health, New Brunswick, New Jersey, United States of America.
Department of Medicine, University of California-San Francisco, San Francisco, California, United States of America.
出版信息
PLoS One. 2024 Feb 7;19(2):e0297685. doi: 10.1371/journal.pone.0297685. eCollection 2024.
AIMS
United States South Asians constitute a fast-growing ethnic group with high prevalence of type 2 diabetes (T2D) despite lower mean BMI and other traditional risk factors compared to other races/ethnicities. Bilirubin has gained attention as a potential antioxidant, cardio-protective marker. Hence we sought to determine whether total bilirubin was associated with prevalent and incident T2D in U.S. South Asians.
METHODS
We conducted a cross-sectional and prospective analysis of the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Total bilirubin was categorized into gender-specific quartiles (Men: <0.6, 0.6, 0.7-0.8, >0.8; Women: <0.5, 0.5, 0.6, >0.6 mg/dl). We estimated odds of type 2 diabetes as well as other cardiovascular (CV) risk factors using multivariable logistic regression.
RESULTS
Among a total 1,149 participants (48% female, mean [SD] age of 57 [9] years), 38% had metabolic syndrome and 24% had T2D. Men and women in the lowest bilirubin quartile had 0.55% and 0.17% higher HbA1c than the highest quartile. Men, but not women, in the lowest bilirubin quartile had higher odds of T2D compared to the highest quartile (aOR [95% CI]; Men: 3.00 [1.72,5.23], Women: 1.15 [0.57,2.31]). There was no association between bilirubin and other CV risk factors.
CONCLUSION
Total bilirubin was inversely associated with T2D in SA men but not women. Longitudinal studies are needed to understand temporality of association.
目的
美国南亚裔是一个快速增长的族群，尽管与其他种族/族裔相比，他们的平均体重指数和其他传统风险因素较低，但 2 型糖尿病（T2D）的患病率却很高。胆红素作为一种潜在的抗氧化剂和心脏保护标志物受到关注。因此，我们试图确定总胆红素与美国南亚裔人群中现患和新发 T2D 是否相关。
方法
我们对在美国生活的南亚裔动脉粥样硬化的中介物（MASALA）研究进行了横断面和前瞻性分析。将总胆红素分为性别特异性四分位（男性：<0.6、0.6、0.7-0.8、>0.8；女性：<0.5、0.5、0.6、>0.6mg/dl）。我们使用多变量逻辑回归估计 2 型糖尿病和其他心血管（CV）风险因素的几率。
结果
在总共 1149 名参与者（48%为女性，平均[SD]年龄为 57[9]岁）中，38%患有代谢综合征，24%患有 T2D。胆红素最低四分位的男性和女性的糖化血红蛋白（HbA1c）比最高四分位高 0.55%和 0.17%。与最高四分位相比，胆红素最低四分位的男性而非女性发生 T2D 的几率更高（比值比[95%CI]；男性：3.00[1.72，5.23]，女性：1.15[0.57，2.31]）。胆红素与其他 CV 风险因素之间没有关联。
结论
总胆红素与 SA 男性的 T2D 呈负相关，但与女性无关。需要进行纵向研究以了解关联的时间性。
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