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What value do zebrafish have to anticancer drug discovery?

作者信息

Xiao Boyuan, Landesman-Bollag Esther, Feng Hui

机构信息

Department of Pharmacology, Physiology & Biophysics, Cancer Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.

Department of Medicine, Section of Hematology and Medical Oncology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.

出版信息

Expert Opin Drug Discov. 2024 Apr;19(4):369-375. doi: 10.1080/17460441.2024.2313454. Epub 2024 Feb 7.

DOI:10.1080/17460441.2024.2313454
PMID:38327017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10950524/
Abstract
摘要

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本文引用的文献

1
Zebrafish Cancer Avatars: A Translational Platform for Analyzing Tumor Heterogeneity and Predicting Patient Outcomes.斑马鱼癌症模型:用于分析肿瘤异质性和预测患者预后的转化平台。
Int J Mol Sci. 2023 Jan 24;24(3):2288. doi: 10.3390/ijms24032288.
2
Why 90% of clinical drug development fails and how to improve it?为什么90%的临床药物研发会失败以及如何改进?
Acta Pharm Sin B. 2022 Jul;12(7):3049-3062. doi: 10.1016/j.apsb.2022.02.002. Epub 2022 Feb 11.
3
Preclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application.上皮性卵巢癌的临床前模型:实际考虑因素及有意义应用的挑战。
Cell Mol Life Sci. 2022 Jun 16;79(7):364. doi: 10.1007/s00018-022-04395-y.
4
Zebrafish Embryos and Larvae as Alternative Animal Models for Toxicity Testing.斑马鱼胚胎和幼鱼作为毒性测试的替代动物模型。
Int J Mol Sci. 2021 Dec 14;22(24):13417. doi: 10.3390/ijms222413417.
5
A zebrafish embryo screen utilizing gastrulation identifies the HTR2C inhibitor pizotifen as a suppressor of EMT-mediated metastasis.利用原肠胚形成对斑马鱼胚胎进行筛选,发现 HTR2C 抑制剂哌唑嗪可作为 EMT 介导的转移的抑制剂。
Elife. 2021 Dec 17;10:e70151. doi: 10.7554/eLife.70151.
6
Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials.斑马鱼疾病模型在药物研发中的应用:从临床前建模到临床试验。
Nat Rev Drug Discov. 2021 Aug;20(8):611-628. doi: 10.1038/s41573-021-00210-8. Epub 2021 Jun 11.
7
Zebrafish, an In Vivo Platform to Screen Drugs and Proteins for Biomedical Use.斑马鱼,一种用于生物医学用途的药物和蛋白质筛选的体内平台。
Pharmaceuticals (Basel). 2021 May 24;14(6):500. doi: 10.3390/ph14060500.
8
Unveiling Tumor Microenvironment Interactions Using Zebrafish Models.利用斑马鱼模型揭示肿瘤微环境相互作用
Front Mol Biosci. 2021 Jan 14;7:611847. doi: 10.3389/fmolb.2020.611847. eCollection 2020.
9
Zebrafish patient avatars in cancer biology and precision cancer therapy.斑马鱼患者生物信息学模型在癌症生物学和精准肿瘤治疗中的应用
Nat Rev Cancer. 2020 May;20(5):263-273. doi: 10.1038/s41568-020-0252-3. Epub 2020 Apr 6.
10
Zebrafish In Vivo Models of Cancer and Metastasis.斑马鱼体内癌症和转移模型。
Cold Spring Harb Perspect Med. 2020 Aug 3;10(8):a037077. doi: 10.1101/cshperspect.a037077.