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金纳米颗粒造影剂的大小对胃肠道及炎症性肠病CT成像的影响。

The effect of the size of gold nanoparticle contrast agents on CT imaging of the gastrointestinal tract and inflammatory bowel disease.

作者信息

Rosario-Berríos Derick N, Pang Amanda, Liu Leening P, Maidment Portia S N, Kim Johoon, Yoon Seokyoung, Nieves Lenitza M, Mossburg Katherine, Adezio Andrew, Noel Peter, Lennon Elizabeth M, Cormode David P

出版信息

bioRxiv. 2024 Jan 23:2024.01.20.576354. doi: 10.1101/2024.01.20.576354.

DOI:10.1101/2024.01.20.576354
PMID:38328034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10849472/
Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD). CT imaging with contrast agents is commonly used for visualizing the gastrointestinal (GI) tract in UC patients. CT is a common imaging modality for evaluating IBD, especially in patients with acute abdominal pain presenting to emergency departments. CT's major limitation lies in its lack of specificity for imaging UC, as the commonly used agents are not well-suited for inflamed areas. Recent studies gastrointestinal tract (GIT) in UC. Further systemic research is needed to explore novel contrast agents that can specifically image disease processes in this disease setting.

摘要

溃疡性结肠炎(UC)是一种慢性炎症性肠病(IBD)。使用造影剂的CT成像常用于观察UC患者的胃肠道(GI)。CT是评估IBD的常用成像方式,尤其是在急诊科出现急性腹痛的患者中。CT的主要局限性在于其对UC成像缺乏特异性,因为常用的造影剂不太适合炎症区域。最近的研究关注UC中的胃肠道(GIT)。需要进一步进行系统性研究,以探索能够在这种疾病背景下特异性成像疾病过程的新型造影剂。