Vaupel P, Kallinowski F, Dave S, Gabbert H, Bastert G
Adv Exp Med Biol. 1985;191:737-51. doi: 10.1007/978-1-4684-3291-6_75.
A new model is presented for the study of oxygen supply and substrate utilization in human tumor tissue. In this approach human tumor material thrives in immune-deficient nude rats. The host chosen allows the continuous evaluation of all relevant parameters. From the data obtained so far it is concluded that this model is a valid tool in investigation of the metabolic status of human tumors.
提出了一种用于研究人类肿瘤组织中氧气供应和底物利用的新模型。在这种方法中,人类肿瘤材料在免疫缺陷的裸鼠体内生长。所选择的宿主允许对所有相关参数进行持续评估。根据目前获得的数据得出结论,该模型是研究人类肿瘤代谢状态的有效工具。