Elmalem J, Garnier R, Nguyen Huu Chieu R, Bismuth C, Efthymiou M L
Ann Med Interne (Paris). 1985;136(8):640-5.
From January 1974 to June 1983, the Paris Poison Control Centre collected 84 cases of overdosage with orphenadrine alone or in combination. Prior papers emphasized fatalities related to orphenadrine poisoning. This retrospective study suggests an underestimated incidence of anticholinergic drugs abuse in our country. The clinical picture of orphenadrine poisoning associates drowsiness, agitation, confusion, delirium and seizures. Anticholinergic symptoms are often noted: mydriasis, sinus tachycardia, dryness of the mouth and urinary retention. No severe cardiac disturbance was found in these patients.
1974年1月至1983年6月，巴黎毒物控制中心收集了84例单独或联合使用邻甲苯海明过量用药的病例。先前的文献强调了与邻甲苯海明中毒相关的死亡案例。这项回顾性研究表明，我国抗胆碱能药物滥用的发生率被低估了。邻甲苯海明中毒的临床表现包括嗜睡、躁动、意识模糊、谵妄和癫痫发作。常出现抗胆碱能症状：瞳孔散大、窦性心动过速、口干和尿潴留。这些患者未发现严重的心脏紊乱。
