Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Neurobiol Aging. 2024 Apr;136:70-77. doi: 10.1016/j.neurobiolaging.2024.01.014. Epub 2024 Feb 2.
Synergies between amyloid-β (Aβ), tau, and neurodegeneration persist along the Alzheimer's disease (AD) continuum. This study aimed to evaluate the extent of spatial coupling between tau and neurodegeneration (atrophy) and its relation to Aβ positivity in mild cognitive impairment (MCI). Data from 409 participants were included (95 cognitively normal controls, 158 Aβ positive (Aβ+) MCI, and 156 Aβ negative (Aβ-) MCI). Florbetapir PET, Flortaucipir PET, and structural MRI were used as biomarkers for Aβ, tau and atrophy, respectively. Individual correlation matrices for tau load and atrophy were used to layer a multilayer network, with separate layers for tau and atrophy. A measure of coupling between corresponding regions of interest (ROIs) in the tau and atrophy layers was computed, as a function of Aβ positivity. Fewer than 25% of the ROIs across the brain showed heightened coupling between tau and atrophy in Aβ+ , relative to Aβ- MCI. Coupling strengths in the right rostral middle frontal and right paracentral gyri, in particular, mediated the association between Aβ burden and cognition in this sample.
淀粉样蛋白-β（Aβ）、tau 蛋白和神经退行性变之间的协同作用在阿尔茨海默病（AD）连续体中持续存在。本研究旨在评估 tau 蛋白与神经退行性变（萎缩）之间的空间耦合程度及其与轻度认知障碍（MCI）中 Aβ 阳性的关系。共纳入 409 名参与者（95 名认知正常对照、158 名 Aβ 阳性（Aβ+）MCI 和 156 名 Aβ 阴性（Aβ-）MCI）。使用氟比他派 PET、氟托西普 PET 和结构 MRI 分别作为 Aβ、tau 和萎缩的生物标志物。使用 tau 负荷和萎缩的个体相关矩阵来分层多层网络，tau 和萎缩分别有单独的层。计算了 tau 和萎缩层中相应感兴趣区域（ROI）之间的耦合程度，作为 Aβ 阳性的函数。与 Aβ- MCI 相比，大脑中不到 25%的 ROI 显示 tau 和萎缩之间的耦合增强。特别是，右额中回和右旁中央回的耦合强度在该样本中介导了 Aβ 负担与认知之间的关联。
