Department of Medical Imaging, Musculoskeletal Imaging, University of Toronto, Toronto, Ontario, Canada.
Institut für Radiologie und Nuklearmedizin, Kantonsspital Baselland, Liestal, Switzerland.
Semin Musculoskelet Radiol. 2024 Feb;28(1):49-61. doi: 10.1055/s-0043-1776428. Epub 2024 Feb 8.
Sarcomas are heterogeneous rare tumors predominantly affecting the musculoskeletal (MSK) system. Due to significant variations in their natural history and variable response to conventional treatments, the discovery of novel diagnostic and prognostic biomarkers to guide therapeutic decision-making is an active and ongoing field of research. As new cellular, molecular, and metabolic biomarkers continue to be discovered, quantitative radiologic imaging is becoming increasingly important in sarcoma management. Radiomics offers the potential for discovering novel imaging diagnostic and predictive biomarkers using standard-of-care medical imaging. In this review, we detail the core concepts of radiomics and the application of radiomics to date in MSK sarcoma research. Also described are specific challenges related to radiomic studies, as well as viewpoints on clinical adoption and future perspectives in the field.
肉瘤是一种异质性的罕见肿瘤，主要影响肌肉骨骼（MSK）系统。由于其自然病史存在显著差异，对常规治疗的反应也各不相同，因此发现新的诊断和预后生物标志物来指导治疗决策是一个活跃且持续的研究领域。随着新的细胞、分子和代谢生物标志物不断被发现，定量放射影像学在肉瘤管理中的作用越来越重要。放射组学为使用标准医疗成像发现新的成像诊断和预测生物标志物提供了可能。在这篇综述中，我们详细介绍了放射组学的核心概念以及迄今为止放射组学在 MSK 肉瘤研究中的应用。还描述了与放射组学研究相关的具体挑战，以及对该领域临床应用和未来展望的观点。
