Kobayashi K, Sakata K, Miyata K, Iino T, Iwasaki S, Takahashi K
Arch Histol Jpn. 1985 Dec;48(5):483-96. doi: 10.1679/aohc.48.483.
Ito cells (fat-storing cells), containing a few lipid droplets, appeared in the Disse's spaces of the Beagle dog liver. They ranged in diameter from 0.5 to 5 micron. The present study revealed that mast cells were also distributed in the Disse's spaces, while they were encountered only in the interlobular connective tissue in other animals. Although mast cells as well as Ito cells were distributed solitarily in the Disse's spaces, pairing of both types of cells could be frequently observed. Direct contact between both cells was verified using both light and electron microscopy. Also encountered were some peculiar figures of certain Kupffer cells engulfing the cytoplasmic processes and secretory granules of mast cells. These findings indicate a previously unknown intimate relationship between the mast cell and other perisinusoidal cells in the dog liver: the Ito cell, Kupffer cell and endothelial cell.
含少量脂滴的贮脂细胞（Ito细胞）出现在比格犬肝脏的狄氏间隙中。它们的直径在0.5至5微米之间。本研究表明，肥大细胞也分布在狄氏间隙中，而在其他动物中仅见于小叶间结缔组织。尽管肥大细胞和贮脂细胞都单独分布在狄氏间隙中，但经常可以观察到这两种细胞成对出现。利用光学显微镜和电子显微镜均证实了两种细胞之间的直接接触。还发现了一些特殊的图像，即某些库普弗细胞吞噬肥大细胞的细胞质突起和分泌颗粒。这些发现表明犬肝脏中肥大细胞与其他肝血窦周细胞（贮脂细胞、库普弗细胞和内皮细胞）之间存在着一种此前未知的密切关系。
