Takahashi Y, Tsubouchi H, Kobayashi K
Arch Histol Jpn. 1978 Sep;41(4):339-49. doi: 10.1679/aohc1950.41.339.
In the normal carp livers, Ito cells (fat-storing cells) could be identified with light and electron microscope within the hepatic sinusoidal wall and actually in the Disse's space, but they were almost lacking lipid droplets in the cytoplasm (empty Ito cells) in contrast to the majority of vertebrate species. After administration of large doses of vitamin A, fat droplets appeared in hypertrophic cytoplasm of enlarged Ito cells, and their size and number increased roughly in proportion to the amounts of vitamin A administered. This evidence was thought to demonstrate that the administration of large doses of vitamin A could convert empty Ito cells into lipid containing ones and further suggested that excess vitamin A administered might be stored in newly prepared lipid droplets of the Ito cells of the liver. In experimentally hypervitaminotic carp, hypertrophic Ito cells showed proliferation of fine filaments in addition to the accumulation of lipid droplets. The correlation between perisinusoidal fibrogenesis in the hepatic lobule and proliferation of cytoplasmic filaments in the Ito cells was discussed.
在正常鲤鱼肝脏中，通过光学显微镜和电子显微镜可在肝血窦壁内以及实际上在狄氏间隙中识别出伊托细胞（贮脂细胞），但与大多数脊椎动物物种不同的是，它们的细胞质中几乎没有脂滴（空伊托细胞）。给予大剂量维生素A后，脂滴出现在增大的伊托细胞肥大的细胞质中，其大小和数量大致与给予的维生素A量成比例增加。这一证据被认为表明给予大剂量维生素A可将空伊托细胞转化为含脂细胞，并进一步表明给予的过量维生素A可能储存在肝脏伊托细胞新形成的脂滴中。在实验性维生素A过多的鲤鱼中，肥大的伊托细胞除了脂滴积累外，还显示出细丝的增殖。讨论了肝小叶内窦周纤维化与伊托细胞细胞质细丝增殖之间的相关性。
