Tatsumi H, Ban T, Fujita H
Arch Histol Jpn. 1985 Dec;48(5):527-39. doi: 10.1679/aohc.48.527.
Morphological changes in the surface mucous cells in the gastric body of the golden hamster occurring during their movement from the lower to the upper portion of the gastric pit have been observed by using scanning as well as transmission electron microscopes. The cells have a wide base and a narrow apex in the lower and middle portions of the pit, while at the opening of the pit to the gastric lumen, they become taller and funnel-like in shape, and are characterized by well developed interdigitations and intermediate filaments sometimes associated with desmosomes. During this transformation of the cell contour, the nucleus moves towards the upper region of the cytoplasm, whereas the Golgi apparatus moves downwards to the infranuclear region. Then, there appear secondary lysosomes showing crinophagy and lipid droplets around or near the Golgi apparatus. Though the basal part of the cells is very small, no images of the detachment of the basal plasma membrane from the basal lamina could be seen even at the site of severe cell degeneration. The tall funnel-shaped cells showing these characteristics are located on the interfoveolar ridges of the underlying fibrous layer and line the free surface of the stomach. Therefore, the interfoveolar cells which have lost the activity of secretory granule production and are going to undergo physiological degeneration are thought to be highly differentiated elements as a covering epithelium to protect the underlying tissue, resembling in this respect the keratinocyte of the epidermis.
利用扫描电子显微镜和透射电子显微镜，观察了金黄地鼠胃体部表面黏液细胞在从胃小凹下部向上部移动过程中的形态变化。在胃小凹的中下部，细胞基部宽而顶部窄，而在胃小凹通向胃腔的开口处，细胞变得更高且呈漏斗状，其特征是有发达的指状突和有时与桥粒相关的中间丝。在细胞轮廓发生这种转变的过程中，细胞核向细胞质的上部区域移动，而高尔基体向下移动到核下区域。然后，在高尔基体周围或附近出现显示自噬现象的次级溶酶体和脂滴。尽管细胞基部非常小，但即使在细胞严重退化的部位，也看不到基底质膜与基膜分离的图像。显示这些特征的高漏斗状细胞位于下方纤维层的小窝间嵴上，并排列在胃的游离表面。因此，已经失去分泌颗粒产生活性并即将发生生理性退化的小窝间细胞被认为是作为覆盖上皮以保护下方组织的高度分化的成分，在这方面类似于表皮的角质形成细胞。
