Knudsen F, Thorgaard Andersen P
Blood Purif. 1985;3(4):179-83. doi: 10.1159/000169410.
Measurement of hypoxanthine/xanthine has been suggested to be a useful indicator of cellular hypoxia. In humans it has been applied for quantitation of asphyxia in the newborn and hypoxic brain damage after cardiac arrest. To investigate if cellular hypoxia occurs during routine hemodialysis we followed leukocyte count, arterial oxygen tension and plasma hypoxanthine/xanthine in 10 stable dialysis patients. Hemodialysis was associated with transitory leukopenia and decrease in oxygen tension. Plasma hypoxanthine/xanthine increased simultaneously with the decrease in leukocyte count and arterial oxygen tension but returned to normal values at the end of treatment. The study demonstrates that routine hemodialysis, even in stable patients, is associated with cellular hypoxia.
次黄嘌呤/黄嘌呤的测量已被认为是细胞缺氧的一个有用指标。在人类中，它已被用于定量新生儿窒息和心脏骤停后的缺氧性脑损伤。为了研究在常规血液透析过程中是否会发生细胞缺氧，我们对10名稳定的透析患者的白细胞计数、动脉血氧张力和血浆次黄嘌呤/黄嘌呤进行了跟踪监测。血液透析与短暂性白细胞减少和血氧张力降低有关。血浆次黄嘌呤/黄嘌呤随着白细胞计数和动脉血氧张力的降低而同时升高，但在治疗结束时恢复到正常水平。该研究表明，即使是稳定的患者，常规血液透析也与细胞缺氧有关。
