134例下颌牙龈鳞状细胞癌患者的临床病理分析
Clinicopathological analysis of 134 patients with squamous cell carcinoma of the mandibular gingiva.
作者信息
Tomioka Hirofumi, Nishii Naoto, Oikawa Yu, Kugimoto Takuma, Kuroshima Takeshi, Hirai Hideaki, Kayamori Kou, Kaida Atsushi, Miura Masahiko, Harada Hiroyuki
机构信息
Department of Oral and Maxillofacial Surgical Oncology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Department of Oral Pathology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
出版信息
Heliyon. 2023 Nov 30;10(1):e23120. doi: 10.1016/j.heliyon.2023.e23120. eCollection 2024 Jan 15.
OBJECTIVE
The accurate assessment of the involvement of mandibular gingival squamous cell carcinoma (SCC) is essential for determining the extent of resection and is also useful for predicting lymph node metastasis and prognosis. The purpose of this study was to investigate the factors for predicting the prognosis.
STUDY DESIGN
We reviewed 134 patients with mandibular gingival SCC treated between 2008 and 2017. The clinical findings, TN stage, relationship between radiographical type and histological pattern, and factors affecting the survival rate were investigated.
RESULTS
The moth-eaten radiographic type was significantly associated with histologically infiltrative pattern. For all 134 cases, the 5-year OS was 89.5 %, and 5-year DSS was 93.9 %. The 5-year DSS was 95.0 % for cN0 and/or pN0 cases and 90.3 % for pN (+) cases, with a significant difference. The significant risk factors for lymph node metastasis were teeth extractions by previous physicians and moth-eaten radiographic type.
CONCLUSION
The risk factor for poor prognosis was lymph node metastasis. In addition, teeth extractions by previous physicians and moth-eaten radiographic type were the risk factors for lymph node metastasis. It is recommended that these cases be treated considering the possibility of cervical lymph node metastasis.
目的
准确评估下颌牙龈鳞状细胞癌（SCC）的累及范围对于确定切除范围至关重要，也有助于预测淋巴结转移和预后。本研究的目的是探讨预测预后的因素。
研究设计
我们回顾了2008年至2017年间接受治疗的134例下颌牙龈SCC患者。调查了临床发现、TN分期、影像学类型与组织学模式之间的关系以及影响生存率的因素。
结果
虫蚀状影像学类型与组织学浸润模式显著相关。在所有134例病例中，5年总生存率（OS）为89.5%，5年无病生存率（DSS）为93.9%。cN0和/或pN0病例的5年DSS为95.0%，pN（+）病例为90.3%，差异有统计学意义。淋巴结转移的显著危险因素是既往医生进行的拔牙和虫蚀状影像学类型。
结论
预后不良的危险因素是淋巴结转移。此外，既往医生进行的拔牙和虫蚀状影像学类型是淋巴结转移的危险因素。建议对这些病例进行治疗时考虑颈部淋巴结转移的可能性。
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