Brantley P J, Carnrike C L, Faulstich M E, Barkemeyer C A
Biofeedback Self Regul. 1985 Jun;10(2):173-80. doi: 10.1007/BF01000752.
Blepharospasm is a chronic condition characterized by involuntary spasmodic closure of the eyelid(s). The present investigation empirically evaluated the relative efficacies of a current pharmacological and a psychological approach in the treatment of blepharospasm. An A-B-A-C-A single-case design was used to compare trihexyphenidyl [Artane] with EMG biofeedback. EMG activity in the frontalis muscle and number of eyeblinks were the dependent variables. The results indicated that Artane had no effect on either dependent measure and that biofeedback had a dramatic treatment effect on both dependent variables. Treatment gains were maintained at a 42-week follow-up. These results are discussed in light of the methodological considerations, the efficacy of psychological intervention, and the need for future research.
眼睑痉挛是一种以眼睑不自主痉挛性闭合为特征的慢性病症。本研究通过实证评估了当前一种药物治疗方法和一种心理治疗方法在治疗眼睑痉挛方面的相对疗效。采用A - B - A - C - A单病例设计，将苯海索[安坦]与肌电图生物反馈进行比较。额肌的肌电图活动和眨眼次数为因变量。结果表明，安坦对任何一项因变量指标均无作用，而生物反馈对两项因变量均产生了显著的治疗效果。治疗效果在42周的随访期内得以维持。根据方法学考量、心理干预的疗效以及未来研究的必要性对这些结果进行了讨论。
