Cai Li, Tan Minyi, Tan Weiqing, Zeng Xia, Wan Nianqing, Wong Stephen Heung-Sang, O'Reilly John, Sun Fenghua, Yang Jiewen, Chen Yajun
Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Health Promotion Centre for Primary and Secondary Schools of Guangzhou Municipality, Guangzhou, China.
Front Endocrinol (Lausanne). 2019 Aug 14;10:549. doi: 10.3389/fendo.2019.00549. eCollection 2019.
Whether irisin concentrations are associated with physical activity (PA) and sedentary time (ST) remains unknown. The role of irisin on cardiometabolic health among children has been contradictory and scarce. This study aimed to examine associations of PA and ST with irisin concentrations and relationships between irisin concentrations and cardiometabolic parameters among children. Additionally, we assessed the interaction between PA or ST and irisin concentrations on cardiometabolic parameters. Basing on a cross-sectional survey of 3,651 general children aged 7-12 years, 575 with different self-reported PA (moderate-vigorous intensity PA ≥ 60 min/day or <150 min/week) and ST (gender-, age-specific ST ≥ 75% or <25% percentile) levels were selected. PA and ST were assessed by the validated international physical activity questionnaires. Fasting blood glucose and lipid profile levels were measured with standard methods by biochemistry analyzer. Plasma irisin concentrations were measured by ELISA. The associations of PA and ST with circulating irisin concentrations were examined by linear regression. Linear regression analysis was also used to estimate associations of circulating irisin concentrations with cardiometabolic variables. Interactions between PA or ST and irisin concentrations on cardiometabolic parameters were calculated using multiple linear regression models with dichotomized factors (low PA and high PA; low ST and high ST). No significant association was observed between circulating irisin concentrations and habitual PA or ST. Irisin concentrations were negatively associated with body mass index (BMI) (β = -0.220), BMI z-score (β = -0.098), waist circumference (β = -0.621), diastolic blood pressure (DBP) (β = -0.561), and triglyceride (β = -0.019) in low PA subgroup, and negatively related to fasting blood glucose (β = -0.040) among high PA subgroup. Moreover, irisin concentrations were negatively associated with BMI (β = -0.157) and fasting blood glucose (β = -0.026) only in high ST subgroup (all < 0.05). We also observed a significant interaction between PA and irisin concentrations on BMI ( = 0.0350), BMI z-score ( = 0.0173), and DBP ( = 0.0068). In summary, irisin concentrations were not associated with habitual PA or ST in children. The negative associations of irisin concentrations with BMI, BMI z-score, and DBP were found only among children being inactive, implying that irisin may contribute to an improvement in health, especially among children with unhealthy lifestyles.
鸢尾素浓度是否与身体活动（PA）和久坐时间（ST）相关尚不清楚。鸢尾素对儿童心脏代谢健康的作用一直存在矛盾且研究较少。本研究旨在探讨儿童PA和ST与鸢尾素浓度之间的关联，以及鸢尾素浓度与心脏代谢参数之间的关系。此外，我们评估了PA或ST与鸢尾素浓度在心脏代谢参数上的相互作用。基于对3651名7至12岁普通儿童的横断面调查，选取了575名自我报告的PA（中等强度至剧烈强度PA≥60分钟/天或<150分钟/周）和ST（按性别和年龄划分的ST≥75%或<25%百分位数）水平不同的儿童。PA和ST通过经过验证的国际身体活动问卷进行评估。空腹血糖和血脂水平通过生化分析仪采用标准方法进行测量。血浆鸢尾素浓度通过酶联免疫吸附测定法（ELISA）进行测量。通过线性回归分析PA和ST与循环鸢尾素浓度之间的关联。线性回归分析还用于估计循环鸢尾素浓度与心脏代谢变量之间的关联。使用具有二分因素（低PA和高PA；低ST和高ST）的多元线性回归模型计算PA或ST与鸢尾素浓度在心脏代谢参数上的相互作用。未观察到循环鸢尾素浓度与习惯性PA或ST之间存在显著关联。在低PA亚组中，鸢尾素浓度与体重指数（BMI）（β = -0.220）、BMI z评分（β = -0.098）、腰围（β = -0.621）、舒张压（DBP）（β = -0.561）和甘油三酯（β = -0.019）呈负相关，在高PA亚组中与空腹血糖（β = -0.040）呈负相关。此外，仅在高ST亚组中，鸢尾素浓度与BMI（β = -0.157）和空腹血糖（β = -0.026）呈负相关（均P<0.05）。我们还观察到PA与鸢尾素浓度在BMI（P = 0.0350）、BMI z评分（P = 0.0173）和DBP（P = 0.0068）上存在显著相互作用。总之，儿童的鸢尾素浓度与习惯性PA或ST无关。仅在不活跃的儿童中发现鸢尾素浓度与BMI、BMI z评分和DBP呈负相关这一现象，这意味着鸢尾素可能有助于改善健康状况，尤其是在生活方式不健康的儿童中。
