El-Gendy Ola A, Alsafi Walaa M, Al-Shafei Khadijah A, Hassan Ahmed A, Adam Ishag
Department of Physiology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Gadarif University, El-Gadarif, Sudan.
BMC Endocr Disord. 2025 Mar 3;25(1):58. doi: 10.1186/s12902-025-01890-8.
The global increase of prediabetes and diabetes in adolescents raises the issue of early prediction of this metabolic disorder via anthropometric parameters, especially in limited resources settings such as Sudan. However, the reliability of these anthropometric predictors is inconclusive. This study aimed to examine the association between anthropometric measures, including body mass index (BMI), hip circumference (HC), waist circumference (WC), waist-to-hip ratio (WHR), body roundness index (BRI), and a body shape index (ABSI), and prediabetes in adolescents in eastern Sudan.
This community-based cross-sectional study was conducted among adolescents in Gadarif City, Eastern Sudan. A questionnaire was used to collect sociodemographic information. Anthropometric and glycated hemoglobin (HbA1c) were performed following the standard procedures. The Receiver Operating Characteristic (ROC) curve was generated. Multivariate binary regression analysis was performed.
Among the 401 adolescents, 186 (46.4%) were female, and 215 (53.6%) were male. The median (IQR) age was 14.1 (12.1-16.3) years. There was no correlation between BMI, WC, HC, WHR, BRI, ABSI, and HbA1c levels. Ninety-five (23.7%) adolescents were identified with prediabetes and 10 (2.5%) with diabetes. In univariate analysis, BRI (OR = 1.24, 95.0% CI = 1.01‒1.52) and BMI (OR = 1.05, 95.0% CI = 1.01‒1.10) were associated with prediabetes. The other anthropometrics and sociodemographic parameters were not associated with prediabetes. In multivariate analysis, BRI and BMI were not associated with prediabetes. All the tested anthropometric parameters, WHR (AUC = 0.51, cutoff = 0.80, sensitivity = 0.69, specificity = 0.44), BRI (AUC = 0.57, cutoff = 1.77, sensitivity = 0.77, specificity = 0.42), ABSI (AUC = 0.51, cutoff = 0.14, sensitivity = 0.77, specificity = 0.31), BMI (AUC = 0.55, cutoff = 18.30 kg/m, sensitivity = 0.45, specificity = 0.67), HC (AUC = 0.54, cutoff = 75.75 cm, sensitivity = 0.73, specificity = 0.36), and WC (AUC = 0.55, cutoff = 66.63 cm, sensitivity = 0.49, specificity = 0.63), had poor reliability in detecting prediabetes in adolescents.
This study demonstrated a lack of reliability of anthropometric parameters in predicting prediabetes among adolescents in eastern Sudan. Further extensive research is recommended in various regions of Sudan.
全球青少年糖尿病前期和糖尿病发病率的上升引发了通过人体测量参数对这种代谢紊乱进行早期预测的问题，尤其是在苏丹等资源有限的地区。然而，这些人体测量预测指标的可靠性尚无定论。本研究旨在探讨包括体重指数（BMI）、臀围（HC）、腰围（WC）、腰臀比（WHR）、身体圆润度指数（BRI）和身体形状指数（ABSI）在内的人体测量指标与苏丹东部青少年糖尿病前期之间的关联。
本基于社区的横断面研究在苏丹东部加达里夫市的青少年中进行。使用问卷收集社会人口学信息。按照标准程序进行人体测量和糖化血红蛋白（HbA1c）检测。绘制受试者工作特征（ROC）曲线。进行多变量二元回归分析。
在401名青少年中，186名（46.4%）为女性，215名（53.6%）为男性。年龄中位数（四分位间距）为14.1（12.1 - 16.3）岁。BMI、WC、HC、WHR、BRI、ABSI与HbA1c水平之间无相关性。95名（23.7%）青少年被诊断为糖尿病前期，10名（2.5%）患有糖尿病。在单变量分析中，BRI（比值比[OR]=1.24，95.0%置信区间[CI]=1.01 - 1.52）和BMI（OR = 1.05，95.0% CI = 1.01 - 1.10）与糖尿病前期相关。其他人体测量指标和社会人口学参数与糖尿病前期无关。在多变量分析中，BRI和BMI与糖尿病前期无关。所有测试的人体测量参数，WHR（曲线下面积[AUC]=0.51，临界值=0.80，敏感性=0.69，特异性=0.44）、BRI（AUC = 0.57，临界值=1.77，敏感性=0.77，特异性=0.42）、ABSI（AUC = 0.51，临界值=0.14，敏感性=0.77，特异性=0.31）、BMI（AUC = 0.55，临界值=18.30 kg/m，敏感性=0.45，特异性=0.67）、HC（AUC = 0.54，临界值=75.75 cm，敏感性=0.73，特异性=0.36）和WC（AUC = 0.55，临界值=66.63 cm），在检测青少年糖尿病前期方面可靠性较差。
本研究表明，人体测量参数在预测苏丹东部青少年糖尿病前期方面缺乏可靠性。建议在苏丹各地区进行进一步的广泛研究。
