UnionDerm, New York, New York, USA.
Lasers Surg Med. 2024 Mar;56(3):233-238. doi: 10.1002/lsm.23767. Epub 2024 Feb 9.
Ultraviolet light and infrared radiation exposure to the chest and neck can result in photoaging changes, such as rhytids, skin roughness, and dyschromia, which can be treated with nonablative fractionated lasers. The low-powered fractionated 1440 and 1927-nm diode lasers have been shown to safely reduce facial photodamage. This study was conducted to investigate the safety and efficacy of a low-powered 1440 and 1927-nm nonablative fractionated diode laser in addressing photoaging symptoms, such as rhytids, skin roughness, and dyschromia, of the neck and chest.
In a prospective, single-arm, nonrandomized study, a cohort of 24 adult female patients with photodamage to their neck and chest received four treatments to these areas, administered at 4-week intervals. Treatments consisted of four passes on high settings with the 1440 nm handpiece followed by four passes with the 1927 nm handpiece. Photographs were taken at each study visit. Study investigators graded wrinkle severity, texture, and mottled pigmentation of the treated area at baseline and follow-up visit, 3 months after the fourth treatment. Subjects also rated clinical improvement of their neck and chest, along with overall appearance. Blinded evaluators used baseline and follow-up photographs to quantify improvements of rhytids and hyperpigmentation of the neck and chest using a 6-point improvement scale.
Of the original cohort, 20 subjects completed all four treatments and 3-month follow-ups. The mean rhytid scores improved by 0.7 ± 1.0 for both neck and chest. Meanwhile, texture scores improved by 1.2 ± 0.4 for the neck and 1.4 ± 0.7 for the chest, with pigment scores improving by 0.5 ± 0.6 for the neck and 0.67 ± 0.7 for the chest. Statistical analysis using paired t-tests, performed on all pre- and posttreatment scores, revealed significant differences (p < 0.05) in wrinkle severity, skin texture, and pigmentation of the neck and chest posttreatment. The degree of improvement was consistent for both the neck and chest areas. Blinded evaluators graded clinical improvements in rhytids and pigmentation at 0.6 ± 1.0 and 0.8 ± 1.2 respectively, corresponding to mild improvement of both neck and chest.
A series of treatments with the nonablative low-energy fractional 1440 and 1927-nm diode laser appears to be safe and effective for improving rhytids, skin texture, and hyperpigmentation of the neck and chest.
胸部和颈部的紫外线和红外线辐射暴露会导致光老化变化,如皱纹、皮肤粗糙和色素沉着不均,这些变化可以用非剥脱性分段式激光治疗。低功率的 1440nm 和 1927nm 半导体激光已被证明可安全减少面部光损伤。本研究旨在探讨低功率 1440nm 和 1927nm 非剥脱性分段式半导体激光治疗颈部和胸部光老化症状(如皱纹、皮肤粗糙和色素沉着不均)的安全性和有效性。
在一项前瞻性、单臂、非随机研究中,24 名成年女性患者的颈部和胸部有光损伤,这些患者每 4 周接受一次治疗,共进行 4 次。治疗包括在高设置下用 1440nm 手柄进行 4 次通过,然后用 1927nm 手柄进行 4 次通过。每次研究就诊时都拍摄照片。在基线和随访就诊时,研究调查人员对治疗区域的皱纹严重程度、纹理和斑驳色素沉着进行分级,并在第四次治疗后 3 个月进行评估。患者还对颈部和胸部的临床改善情况以及整体外观进行了评分。盲法评估者使用基线和随访照片,使用 6 分改善量表对颈部和胸部的皱纹和色素沉着进行量化评估。
在最初的队列中,20 名受试者完成了所有 4 次治疗和 3 个月的随访。颈部和胸部的平均皱纹评分分别改善了 0.7±1.0。同时,颈部的纹理评分改善了 1.2±0.4,胸部的纹理评分改善了 1.4±0.7,颈部的色素评分改善了 0.5±0.6,胸部的色素评分改善了 0.67±0.7。使用配对 t 检验对所有治疗前后的评分进行统计学分析,结果显示治疗后颈部和胸部的皱纹严重程度、皮肤纹理和色素沉着均有显著差异(p<0.05)。颈部和胸部区域的改善程度一致。盲法评估者对皱纹和色素沉着的临床改善程度分别评为 0.6±1.0 和 0.8±1.2,对应于颈部和胸部的轻度改善。
一系列使用非剥脱性低能量分段式 1440nm 和 1927nm 半导体激光治疗可安全有效地改善颈部和胸部的皱纹、皮肤纹理和色素沉着不均。