由具有多个CYP51A突变的三唑耐药烟曲霉引起的致命性侵袭性肺曲霉病和脑曲霉病。 - Suppr

Fatal invasive pulmonary and cerebral aspergillosis due to triazole-resistant Aspergillus fumigatus with multiple CYP51A mutations.

作者信息

Atamna Alaa, Yeshurun Moshe, Shargian Liat, Raanani Pia, Kramer Mordechai, Ben Zvi Haim, Ben Ami Ronen, Marr Kieren A, Bishara Jihad

机构信息

Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel.

Tel Aviv Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.

出版信息

J Antimicrob Chemother. 2024 May 2;79(5):1191-1192. doi: 10.1093/jac/dkae038.

DOI:10.1093/jac/dkae038

PMID:38334380

Abstract

摘要

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Fatal invasive pulmonary and cerebral aspergillosis due to triazole-resistant Aspergillus fumigatus with multiple CYP51A mutations.由具有多个CYP51A突变的三唑耐药烟曲霉引起的致命性侵袭性肺曲霉病和脑曲霉病。

J Antimicrob Chemother. 2024 May 2;79(5):1191-1192. doi: 10.1093/jac/dkae038.

Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis.烟曲霉中 G448S 取代导致对伏立康唑耐药的脑曲霉病患者。

J Clin Microbiol. 2012 Jul;50(7):2531-4. doi: 10.1128/JCM.00329-12. Epub 2012 May 9.

Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation With Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015.1999-2015 年，三级癌症中心曲霉菌对唑类药物的体外敏感性模式变化及其与曲霉病结局的相关性。

Clin Infect Dis. 2017 Jul 15;65(2):216-225. doi: 10.1093/cid/cix297.

Progressive Dispersion of Azole Resistance in Aspergillus fumigatus: Fatal Invasive Aspergillosis in a Patient with Acute Myeloid Leukemia Infected with an A. fumigatus Strain with a TR Y121F M172I T289A Allele.烟曲霉中唑类耐药性的渐进性扩散：一例感染携带TR Y121F M172I T289A等位基因烟曲霉菌株的急性髓系白血病患者发生致命性侵袭性曲霉病

Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00270-17. Print 2017 Aug.

In vitro activity of the novel antifungal compound F901318 against difficult-to-treat Aspergillus isolates.新型抗真菌化合物 F901318 对难治疗的曲霉属分离株的体外活性。

J Antimicrob Chemother. 2017 Sep 1;72(9):2548-2552. doi: 10.1093/jac/dkx177.

Triazole-resistant , an industrially important black spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China.从中国侵袭性肺曲霉病患者中分离到的三唑耐药、在东亚发酵中具有重要工业意义的黑曲霉。

Emerg Microbes Infect. 2022 Dec;11(1):1435-1438. doi: 10.1080/22221751.2022.2076614.

Insight into the Significance of Aspergillus fumigatus cyp51A Polymorphisms.曲霉属烟曲霉 CYP51A 多态性的意义解析。

Antimicrob Agents Chemother. 2018 May 25;62(6). doi: 10.1128/AAC.00241-18. Print 2018 Jun.

High-frequency triazole resistance found In nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease.从慢性真菌病患者肺部的不可培养烟曲霉中发现高频三唑耐药性。

Clin Infect Dis. 2011 May;52(9):1123-9. doi: 10.1093/cid/cir179.

Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.在印度从携带 cyp51A 基因 TR/L98H 突变的多唑耐药烟曲霉分离株。

J Antimicrob Chemother. 2012 Feb;67(2):362-6. doi: 10.1093/jac/dkr443. Epub 2011 Oct 25.

Aspergillus fumigatus strains with mutations in the cyp51A gene do not always show phenotypic resistance to itraconazole, voriconazole, or posaconazole.烟曲霉中细胞色素 P45051A 基因突变株并不总是表现出对伊曲康唑、伏立康唑或泊沙康唑的表型耐药性。

Antimicrob Agents Chemother. 2011 May;55(5):2460-2. doi: 10.1128/AAC.01358-10. Epub 2011 Feb 14.

引用本文的文献

Trends of Azole-Resistant Aspergillus Fumigatus Susceptibility Over 12 Years from a German ECMM Excellence Center.来自德国欧洲医学真菌学联盟卓越中心的12年间烟曲霉对唑类药物耐药性的变化趋势

Mycopathologia. 2025 Apr 5;190(2):34. doi: 10.1007/s11046-025-00941-x.

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Fatal invasive pulmonary and cerebral aspergillosis due to triazole-resistant Aspergillus fumigatus with multiple CYP51A mutations.

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