Department of Ophthalmology, Miguel Servet University Hospital, 1-3 Isabel la Católica Street, 50009, Zaragoza, Spain.
Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.
Int Ophthalmol. 2024 Feb 9;44(1):40. doi: 10.1007/s10792-024-03016-w.
To evaluate the influence of hydroxychloroquine (HCQ) in choroidal thickness (CT) in patients with systemic lupus erythematous (SLE), considering the possible impact of disease activity on the choroid.
Cross-sectional study comparing three groups: two groups of SLE patients treated with HCQ without HCQ-retinopathy (32 eyes/32 patients with < 5 years of HCQ (group 1) and 44 eyes/44 patients with > 5 years of HCQ (group 2)), and an age-matched healthy control group of 46 eyes/46 patients (group 3). A complete ophthalmic examination was performed, including swept-source optical coherence tomography (SS-OCT) Triton (Topcon). Data were correlated to systemic disease activity parameters.
CT was thicker in group 1 compared to group 3 in central, nasal, and superior sectors, and to group 2 in inner superior and outer inferior sectors (p < 0.05). In the correlation analysis, disease activity and CT were inversely correlated in most sectors (p < 0.05). In the regression analysis, HCQ was related to thinner CT in temporal and inferior sectors and disease activity with variations in nasal sectors (p < 0.05).
In SLE patients, HCQ is correlated to decreased CT, especially in the inferior and temporal areas. The choroid shows different responses to SLE activity and HCQ, and some sectors may be more sensitive than others.
评估羟氯喹（HCQ）对系统性红斑狼疮（SLE）患者脉络膜厚度（CT）的影响，同时考虑疾病活动对脉络膜的可能影响。
这是一项横断面研究，比较了三组患者：两组未发生 HCQ 相关视网膜病变的 SLE 患者（接受 HCQ 治疗且用药时间<5 年的 32 只眼/32 例患者，记为组 1；用药时间>5 年的 44 只眼/44 例患者，记为组 2），以及年龄匹配的健康对照组的 46 只眼/46 例患者（组 3）。所有患者均接受全面的眼科检查，包括扫频源光学相干断层扫描（SS-OCT）Triton（Topcon）。将数据与系统性疾病活动参数相关联。
与组 3 相比，组 1 的 CT 在中央、鼻侧和上侧区域更厚，与组 2 的内上侧和外下侧区域相比也更厚（p<0.05）。在相关性分析中，大多数区域的疾病活动与 CT 呈负相关（p<0.05）。在回归分析中，HCQ 与颞侧和下侧区域的 CT 变薄相关，疾病活动与鼻侧区域的 CT 变化相关（p<0.05）。
在 SLE 患者中，HCQ 与 CT 变薄相关，尤其是在下侧和颞侧区域。脉络膜对 SLE 活动和 HCQ 的反应不同，某些区域可能比其他区域更敏感。
