Department of Ophthalmology, Kastamonu University Faculty of Medicine, Kastamonu, Turkey.
Department of Ophthalmology, İzmir Katip Çelebi University Atatürk Educating and Research Hospital, İzmir, Turkey.
Int Ophthalmol. 2021 Jan;41(1):143-150. doi: 10.1007/s10792-020-01561-8. Epub 2020 Aug 26.
To evaluate the choroidal and retinal layers with optical coherence tomography (OCT) and retinal microvascular structures with optical coherence tomography angiography (OCTA) in systemic lupus erythematosus (SLE) patients.
In this prospective, cross-sectional and comparative study, a total of 35 SLE patients and 35 healthy control participants were included. SLE patients who were using hydroxychloroquine (HCQ) and/or immunosuppressive agents are evaluated with OCT and OCTA. SLE patients who have no HCQ maculopathy observed in OCT were included in the patient group.
Mean macular thickness and ganglion cell inner plexiform layer (GC-IPL) thicknesses were thinner in the patient group. When the parameters obtained with OCTA were evaluated, vessel (VD) and perfusion density (PD) were significantly lower in the patient group. Central foveal thickness and foveal avascular zone parameters were negatively correlated. In addition, VD and PD, and GC-IPL thicknesses were positively correlated.
Application of OCTA for the evaluation of microvasculature in SLE patients may be useful in subclinical changes.
使用光学相干断层扫描（OCT）评估系统性红斑狼疮（SLE）患者的脉络膜和视网膜层，使用光相干断层扫描血管造影（OCTA）评估视网膜微血管结构。
在这项前瞻性、横断面和对照研究中，共纳入 35 名 SLE 患者和 35 名健康对照者。对接受羟氯喹（HCQ）和/或免疫抑制剂治疗的 SLE 患者进行 OCT 和 OCTA 评估。将 OCT 未观察到 HCQ 黄斑病变的 SLE 患者纳入患者组。
与对照组相比，患者组的黄斑厚度和神经节细胞内丛状层（GC-IPL）厚度变薄。当评估 OCTA 获得的参数时，患者组的血管（VD）和灌注密度（PD）显著降低。中央凹视网膜厚度和无血管区参数呈负相关。此外，VD、PD 和 GC-IPL 厚度呈正相关。
OCTA 对 SLE 患者微血管的评估可能有助于发现亚临床变化。
