Tanaka T, Maesaka H, Suwa S
Endocrinol Jpn. 1985 Dec;32(6):891-7. doi: 10.1507/endocrj1954.32.891.
Somatomedin (SM) activity, GH, T3 and T4 were investigated in 6 girls with anorexia nervosa during hospitalization and at outpatient clinic. On admission, serum T3 (27-62 ng/dl) and SM activity (0.24-0.55 U/ml) were low in all cases, while basal GH was extremely high in 2 cases. A significant negative correlation was found between SM activity and basal GH during the course of treatment (r = -0.61, p less than 0.02). The change in SM activity was related to that of the serum T3 level and a significant positive correlation was found between SM activity and serum T3 (r = 0.80, p less than 0.001). These data suggest that decreased SM activity may suppress the inhibitory effect of SM on GH release and may raise the basal GH level. SM activity is one of the indicators of the nutritional condition in anorexia nervosa as well as the serum T3 concentration.
对6名神经性厌食症女孩在住院期间及门诊时的生长调节素（SM）活性、生长激素（GH）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）进行了研究。入院时，所有病例的血清T3（27 - 62 ng/dl）和SM活性（0.24 - 0.55 U/ml）均较低，而基础GH在2例中极高。在治疗过程中，发现SM活性与基础GH之间存在显著负相关（r = -0.61，p < 0.02）。SM活性的变化与血清T3水平的变化相关，且SM活性与血清T3之间存在显著正相关（r = 0.80，p < 0.001）。这些数据表明，SM活性降低可能会抑制SM对GH释放的抑制作用，并可能提高基础GH水平。SM活性以及血清T3浓度是神经性厌食症营养状况的指标之一。
