Rappaport R, Prevot C, Czernichow P
Acta Paediatr Scand. 1980 Jan;69(1):37-41. doi: 10.1111/j.1651-2227.1980.tb07026.x.
Anorexia nervosa in childhood and adolescence, associated with impaired growth can be considered as a form of chronic malnutrition. Twelve patients aged 11 to 17 years were investigated. In spite of increased GH secretion, plasma somatomedin activities were diminished in 8 cases. Plasma T4, T3 and arginine stimulated insulin secretion were also decreased. In six patients who gained weight a significant negative correlation was found between weight deficit and plasma somatomedin activity. Prolonged administration of growth hormone in one case did not stimulate the generation of somatomedin activity. Nutrition and increased insulin secretion could plan a role in changes observed during recovery.
儿童和青少年期神经性厌食症伴有生长发育受损，可被视为一种慢性营养不良形式。对12例年龄在11至17岁的患者进行了调查。尽管生长激素分泌增加，但8例患者的血浆生长调节素活性降低。血浆甲状腺素、三碘甲状腺原氨酸以及精氨酸刺激的胰岛素分泌也减少。在6例体重增加的患者中，发现体重不足与血浆生长调节素活性之间存在显著负相关。在1例患者中，长期给予生长激素并未刺激生长调节素活性的产生。营养和胰岛素分泌增加可能在恢复过程中观察到的变化中起作用。
