热不稳定延伸因子2在小鼠和大鼠肝脏中的积累。
Accumulation of heat-labile elongation factor 2 in the liver of mice and rats.
作者信息
Takahashi R, Mori N, Goto S
出版信息
Exp Gerontol. 1985;20(6):325-31. doi: 10.1016/0531-5565(85)90012-9.
PMID:3833544
Abstract
Age-related changes of polypeptide chain elongation factor 2 (EF-2) in mouse and rat livers were investigated. The percentage of heat-labile components in EF-2 was 5 to 10% in young animals and 15 to 45% in old ones. These results and other findings (Takahashi et al., in press) support the idea that decrease in translational activity in old animals is due, in part, to alterations of protein components of the translational system.
摘要
研究了小鼠和大鼠肝脏中多肽链延伸因子2（EF-2）的年龄相关变化。在幼龄动物中，EF-2中热不稳定成分的百分比为5%至10%，而在老龄动物中为15%至45%。这些结果和其他发现（高桥等人，即将发表）支持这样一种观点，即老龄动物翻译活性的降低部分归因于翻译系统蛋白质成分的改变。
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