School of Cardiovascular Medicine and Sciences, King's College London, London, United Kingdom.
Cardiovascular Division, Chaim Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel.
J Cardiovasc Pharmacol. 2024 May 1;83(5):364-376. doi: 10.1097/FJC.0000000000001542.
Myocarditis is an inflammatory disease of the myocardium characterized by a great heterogeneity of presentation and evolution. Treatment of myocarditis is often supportive, and the evidence for immunosuppression is scarce and debated. Conventional treatment is based on clinical presentation, ranging from conservative to advanced mechanical assist devices. In this setting, immunosuppression and immunomodulation therapies are mostly reserved for patients presenting with major clinical syndromes. In this review, we will summarize the current evidence and strategies for conventional and immunosuppressive treatments for patients presenting with acute myocarditis.
心肌炎是一种心肌炎症性疾病,其表现和演变具有很大的异质性。心肌炎的治疗通常是支持性的,免疫抑制的证据很少且存在争议。常规治疗基于临床表现,从保守治疗到先进的机械辅助设备不等。在这种情况下,免疫抑制和免疫调节治疗主要保留给出现重大临床综合征的患者。在这篇综述中,我们将总结急性心肌炎患者的常规和免疫抑制治疗的现有证据和策略。