Burian Julia, Buser Peter, Eriksson Urs
Experimental Critical care Medicine, Department of Research, university Hospital, Basel, Switzerland.
Swiss Med Wkly. 2005 Jun 25;135(25-26):359-64. doi: 10.4414/smw.2005.10940.
Viral myocarditis is a frequent and often unrecognised cause of post-inflammatory cardiomyopathy. The role of viral persistence and heart-specific autoimmunity in the development of myocarditis and heart failure is still controversial. This review updates the current view on the immunological mechanisms of disease development and addresses the current and future role of immunomodulation and immunosuppression as treatment options for defined subgroups of patients with myocarditis or dilated cardiomyopathy.
病毒性心肌炎是炎症后心肌病常见且常未被认识的病因。病毒持续存在和心脏特异性自身免疫在心肌炎和心力衰竭发生中的作用仍存在争议。本综述更新了关于疾病发展免疫机制的当前观点，并探讨了免疫调节和免疫抑制作为心肌炎或扩张型心肌病特定亚组患者治疗选择的当前及未来作用。
