Department of Pharmacology and Chemical Biology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Institute of Interdisciplinary Integrative Biomedical Research, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China.
Adv Drug Deliv Rev. 2024 Apr;207:115196. doi: 10.1016/j.addr.2024.115196. Epub 2024 Feb 7.
Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose-to-brain pathway and how the various biopharmaceutical factors affect brain delivery efficacy remains unclear. In this review, we comprehensively summarized the anatomical and physiological characteristics of the nose-to-brain pathway and the obstacles that hinder brain delivery. We then outlined the interaction between nanoparticles and this pathway and reviewed the biomedical applications of various nanoparticulate drug delivery systems for nose-to-brain drug delivery. This review aims at inspiring innovative approaches for enhancing the effectiveness of nose-to-brain drug delivery in the treatment of different brain disorders.
鼻腔给药为药物直达中枢神经系统提供了一种直接且无创的方法。纳米颗粒作为载体在增强脑递药效果方面发挥着关键作用。然而，纳米颗粒与鼻脑通路的相互作用以及各种生物制药因素如何影响脑递药效果尚不清楚。在这篇综述中，我们全面总结了鼻脑通路的解剖学和生理学特征以及阻碍脑递药的障碍。然后，我们概述了纳米颗粒与该通路的相互作用，并综述了各种纳米颗粒药物传递系统在鼻内递药治疗不同脑部疾病中的生物医学应用。本文旨在为提高鼻内递药治疗不同脑部疾病的效果提供创新思路。
