Patel Amit A, Patel Ravish J, Patel Shachi R
Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus Changa, Anand - 388 421, Gujarat, India.
Curr Drug Deliv. 2018;15(4):461-469. doi: 10.2174/1567201814666171013150534.
Intranasal drug delivery system provides distinct advantage over conventional drug delivery system for a drug that is pharmacokenetically or biologically unstable. Major concern for the treatment of central nervous system diseases is, low concentration of therapeutically active molecule within brain as blood brain barrier is creating obstacle, where intranasal drug delivery provides direct transport of therapeutically active moiety into brain via olfactory or trigeminal pathway. Nasal mucosa provides distinct advantages like improved bioavailability, law dose and quick onset of action and high patient compliance, and the major disadvantage is residence time of drug and irreversible entrapment of drug. This article provides anatomical and physiological information about nasal route and various factors. Article discusses various types of nanoparticles used intranasally and moreover article also emphasizes patents, formulation under development and some.
对于药代动力学或生物学不稳定的药物，鼻内给药系统相对于传统给药系统具有明显优势。治疗中枢神经系统疾病的主要问题是，由于血脑屏障造成阻碍，脑内治疗活性分子浓度较低，而鼻内给药可通过嗅觉或三叉神经途径将治疗活性部分直接转运至脑内。鼻黏膜具有生物利用度提高、剂量低、起效快和患者顺应性高等明显优势，主要缺点是药物停留时间和药物的不可逆截留。本文提供了有关鼻腔途径的解剖学和生理学信息以及各种因素。文章讨论了鼻内使用的各种类型的纳米颗粒，此外还强调了专利、正在开发的制剂等。
