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澳大利亚心血管联盟视角:整合澳大利亚研究流程、政策与实践中的心脏肿瘤学

Integrating Cardio-Oncology Across the Research Pipeline, Policy, and Practice in Australia-An Australian Cardiovascular Alliance Perspective.

作者信息

Singleton Anna C, Redfern Julie, Diaz Abbey, Koczwara Bogda, Nicholls Stephen J, Negishi Kazuaki, La Gerche Andre, Playford David, Conyers Rachel, Cehic Daniel A, Garvey Gail, Williams Trent D, Hunt Lee, Doyle Kerry, Figtree Gemma A, Ngo Doan T M, Sverdlov Aaron L

机构信息

Faculty of Medicine and Health, The University of Sydney School of Health Sciences, Sydney, NSW, Australia.

Faculty of Medicine and Health, The University of Sydney School of Health Sciences, Sydney, NSW, Australia; George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.

出版信息

Heart Lung Circ. 2024 May;33(5):564-575. doi: 10.1016/j.hlc.2024.01.011. Epub 2024 Feb 9.

Abstract

Over 18 million people worldwide were diagnosed with cancer in 2020, including over 150,000 people in Australia. Although improved early detection and treatment have increased the survival rates, cardiotoxic treatment and inadequate management of cardiovascular risk factors have resulted in cardiovascular disease (CVD) being one of the leading causes of non-cancer-related death and disability among cancer survivors. International guidelines outline the standards of care for CVD risk surveillance and management. However, Australian cardio-oncology policies and clinical guidelines are limited. There is increasing growth of cardio-oncology research in Australia and support from leading Australian professional bodies and advocacy and research networks, including the Cardiac Society of Australia and New Zealand, the Clinical Oncology Society of Australia, the National Heart Foundation of Australia, and the Australian Cardiovascular Alliance (ACvA). Thus, opportunities to drive multidisciplinary cardio-oncology initiatives are growing, including grant funding, position statements, and novel research to inform new policies. The ACvA has a unique flagship structure that spans the translational research pipeline from drug discovery to implementation science. This article aims to highlight how multidisciplinary cardio-oncology innovations could intersect with the seven ACvA flagships, and to showcase Australian achievements in cardio-oncology thus far. We summarise eight key priority areas for future cardio-oncology research that emerged. These strategies will strengthen cardio-oncology research and care in Australia, and drive new guidelines, policies, and government initiatives to ensure equity in health outcomes for all cardio-oncology patients.

摘要

2020年,全球有超过1800万人被诊断出患有癌症,其中澳大利亚有超过15万人。尽管早期检测和治疗的改善提高了生存率,但心脏毒性治疗以及心血管危险因素管理不足,导致心血管疾病(CVD)成为癌症幸存者中非癌症相关死亡和残疾的主要原因之一。国际指南概述了心血管疾病风险监测和管理的护理标准。然而,澳大利亚的心脏肿瘤学政策和临床指南有限。澳大利亚心脏肿瘤学研究不断发展,并得到了澳大利亚主要专业机构以及倡导和研究网络的支持,包括澳大利亚和新西兰心脏学会、澳大利亚临床肿瘤学会、澳大利亚国家心脏基金会以及澳大利亚心血管联盟(ACvA)。因此,推动多学科心脏肿瘤学倡议的机会越来越多,包括资助资金、立场声明以及为新政策提供信息的新颖研究。ACvA拥有独特的旗舰结构,涵盖了从药物发现到实施科学的转化研究流程。本文旨在强调多学科心脏肿瘤学创新如何与ACvA的七个旗舰项目相交,并展示澳大利亚迄今为止在心脏肿瘤学方面取得的成就。我们总结了未来心脏肿瘤学研究出现的八个关键优先领域。这些策略将加强澳大利亚的心脏肿瘤学研究和护理,并推动新的指南、政策和政府倡议,以确保所有心脏肿瘤学患者在健康结果方面的公平性。

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