Institute for Social and Economic Research, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK.
BMC Public Health. 2024 Feb 9;24(1):416. doi: 10.1186/s12889-024-17888-1.
Previous research has demonstrated a correlation between chronic stress and chronic pain (CP). However, there have been few studies examining the prospective association of allostatic load (AL)-the biological processes related to stress-with CP.
We firstly conducted latent class analysis to identify phenotypes of AL using a community-dwelling sample, the Midlife in the United States. Multinomial logistic regression models were used to examine the prospective association between phenotypes of AL at MIDUS 2 biomarker project and the presence of CP, CP interference and the number of CP sites at MIDUS 3.
Three phenotypes of AL, low biological dysregulation, parasympathetic dysregulation and metabolic dysregulation, were identified. Compared to low biological dysregulation group, participants experiencing metabolic dysregulation phenotype of AL at MIDUS 2 had higher risks of having high-interference CP (RRR = 2.00, 95% CI: 1.06, 3.79, P < 0.05) and 3 or more CP sites (RRR = 2.03, 95% CI: 1.08, 3.83, P < 0.05) at MIDUS 3.
The findings indicate that focusing on mitigating the metabolic dysfunction phenotype of AL has the potential to be an efficacious strategy for alleviating future CP bodily widespreadness and high CP interference.
先前的研究表明，慢性压力与慢性疼痛（CP）之间存在关联。然而，很少有研究探讨应激相关的适应负荷（AL）——与应激相关的生物过程——与 CP 的前瞻性关联。
我们首先使用美国中年人群的中生活研究（MIDUS）进行潜在类别分析，以确定 AL 的表型。使用多项逻辑回归模型来检验 MIDUS 2 生物标志物研究中 AL 的表型与 CP 的存在、CP 干扰以及 MIDUS 3 中 CP 部位数量的前瞻性关联。
确定了三种 AL 表型，即低生物调节紊乱、副交感神经调节紊乱和代谢调节紊乱。与低生物调节紊乱组相比，在 MIDUS 2 中经历代谢调节紊乱表型的 AL 的参与者具有更高的发生高干扰 CP（RRR=2.00，95%CI：1.06，3.79，P<0.05）和 3 个或更多 CP 部位（RRR=2.03，95%CI：1.08，3.83，P<0.05）的风险。
研究结果表明，关注减轻代谢功能紊乱的 AL 表型可能是缓解未来 CP 身体广泛性和高 CP 干扰的有效策略。
