Laboratory of Cellular Neurobiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Laboratory of Functional Neuroanatomy of Pain, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil; Translational Neuropsychiatry Unit (TNU), Aarhus University, Aarhus, Denmark.
Neurosci Biobehav Rev. 2021 Dec;131:1056-1075. doi: 10.1016/j.neubiorev.2021.10.019. Epub 2021 Oct 21.
Parkinson's disease (PD) is a progressive disabling brain disorder. Physical exercise has been shown to alleviate the symptoms of PD and, consequently, improve patient quality of life. Exercise mechanisms involved in beneficial effects on PD have been widely investigated. This study aims to systematically review the literature on the use of treadmill exercise in PD animal models. The study was conducted according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Searches were conducted in MEDLINE, EMBASE, and ISI databases. In total, 78 studies were included. The dopaminergic system, behavior, neuroplasticity, neuroinflammation, mitochondria, and musculoskeletal systems were some of the outcomes evaluated by the selected studies. Based on the systematic review center for laboratory animal experimentation (SYRCLE) RoB tool, the methodologies revealed a high risk of bias and lack of information about study design, which needs attention for data reproducibility. This review can guide future studies that aim to fill existing gaps regarding the effects of treadmill exercise in PD animal models.
帕金森病（PD）是一种进行性致残的脑部疾病。运动已被证明可以缓解 PD 的症状，从而提高患者的生活质量。运动对 PD 有益影响的机制已被广泛研究。本研究旨在系统地回顾 treadmill 运动在 PD 动物模型中的应用文献。研究按照系统评价和荟萃分析的首选报告项目（PRISMA）进行。在 MEDLINE、EMBASE 和 ISI 数据库中进行了检索。共纳入 78 项研究。多巴胺能系统、行为、神经可塑性、神经炎症、线粒体和肌肉骨骼系统是选定研究评估的一些结果。基于系统评价中心的实验室动物实验（SYRCLE）RoB 工具，这些方法学显示出高偏倚风险和缺乏关于研究设计的信息，这需要注意数据的可重复性。本综述可以指导未来的研究，旨在填补 treadmill 运动在 PD 动物模型中的作用的现有空白。
