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炎症——心肌炎与致心律失常性心肌病之间的潜在联系。

Inflammation-A Possible Link between Myocarditis and Arrhythmogenic Cardiomyopathy.

作者信息

Lala Ioan Radu, Pop-Moldovan Adina

机构信息

Departement of Cardiology, Arad Emergency Clinical County Hospital, 310037 Arad, Romania.

Department of Cardiology, Arad Western University Vasile Goldis, 310414 Arad, Romania.

出版信息

Diagnostics (Basel). 2024 Jan 24;14(3):248. doi: 10.3390/diagnostics14030248.

Abstract

Arrhythmogenic cardiomyopathy is a primary genetic disease caused by mutations in the desmosome genes. Ever since the introduction of new imaging techniques, like cardiovascular magnetic resonance, the diagnosis of arrhythmogenic cardiomyopathy has become more challenging as left ventricular or biventricular variants may have resemblance to other cardiomyopathies or myocarditis. Not only this but they may also share an acute phase, which might cause even more confusion and misdiagnoses and influence the prognosis and outcome. In this case report, we present a 31-year-old patient with multiple clinical pictures: his symptoms were acute chest pain, new onset of heart failure and arrhythmia symptoms, which determined a dynamic change in clinical diagnosis and management, ultimately taking into consideration arrhythmogenic cardiomyopathy. Through the article, we try to uncover and explain common pathophysiological pathways shared by arrhythmogenic cardiomyopathy and other clinical entities with a special focus on inflammation. The final question remains:

摘要

致心律失常性心肌病是一种由桥粒基因突变引起的原发性遗传疾病。自从引入新的成像技术,如心血管磁共振成像以来,致心律失常性心肌病的诊断变得更具挑战性,因为左心室或双心室型可能与其他心肌病或心肌炎相似。不仅如此,它们还可能有一个急性期,这可能会导致更多的混淆和误诊,并影响预后和结局。在本病例报告中,我们介绍了一名31岁的患者,他有多种临床表现:症状为急性胸痛、新发心力衰竭和心律失常症状,这些症状决定了临床诊断和治疗的动态变化,最终考虑到了致心律失常性心肌病。通过本文,我们试图揭示并解释致心律失常性心肌病与其他临床实体共有的常见病理生理途径,特别关注炎症。最后的问题仍然是:

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6898/10855458/98f7ca140220/diagnostics-14-00248-g001.jpg

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