Taylor D M, Seidel A, Doerfel H
Int J Nucl Med Biol. 1985;12(5):387-91. doi: 10.1016/s0047-0740(85)80009-7.
The whole body retention of 181Hf was studied in marmosets (Callithrex jacchus) and found to be closely similar to that in rats and Chinese hamsters. Limited tissue distribution studies suggest a higher uptake in liver and much lower deposition in skin and muscle in the marmoset as compared to the rat or Chinese hamster. Studies in Chinese hamsters showed that treatment with the chelating agent diethylenetriaminepentaacetic acid resulted in only a small reduction in the whole body retention of 181Hf. The absorption of orally administered 181Hf, in various chemical forms, was found to be between 0.04 and 0.13% of the ingested dose and was unaffected by age between 5 and 21 months but was increased by fasting. The measured absorption of 181Hf in Chinese hamsters and in rats was similar to that of plutonium suggesting that radiohafnium could be used as a surrogate for plutonium for selected studies in human volunteers.
在狨猴（Callithrex jacchus）身上研究了181铪的全身滞留情况，发现其与大鼠和中国仓鼠的情况非常相似。有限的组织分布研究表明，与大鼠或中国仓鼠相比，狨猴肝脏中的摄取量更高，而皮肤和肌肉中的沉积量则低得多。在中国仓鼠身上进行的研究表明，用螯合剂二乙烯三胺五乙酸处理只会使181铪的全身滞留量略有减少。研究发现，以各种化学形式口服的181铪的吸收率在摄入剂量的0.04%至0.13%之间，5至21个月的年龄对其没有影响，但禁食会使其增加。在中国仓鼠和大鼠身上测得的181铪的吸收率与钚相似，这表明放射性铪可作为钚的替代物用于人类志愿者的特定研究。
