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开环聚合的六和八成员的外消旋环状酯的可生物降解材料。

Ring Opening Polymerization of Six- and Eight-Membered Racemic Cyclic Esters for Biodegradable Materials.

机构信息

Department of Chemical Sciences, Università degli Studi di Napoli Federico II, Via Cintia, 80126 Napoli, Italy.

Scuola Superiore Meridionale, Largo San Marcellino 10, 80138 Napoli, Italy.

出版信息

Int J Mol Sci. 2024 Jan 29;25(3):1647. doi: 10.3390/ijms25031647.

DOI:10.3390/ijms25031647
PMID:38338928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10855523/
Abstract

The low percentage of recyclability of the polymeric materials obtained by olefin transition metal (TM) polymerization catalysis has increased the interest in their substitution with more eco-friendly materials with reliable physical and mechanical properties. Among the variety of known biodegradable polymers, linear aliphatic polyesters produced by ring-opening polymerization (ROP) of cyclic esters occupy a prominent position. The polymer properties are highly dependent on the macromolecule microstructure, and the control of stereoselectivity is necessary for providing materials with precise and finely tuned properties. In this review, we aim to outline the main synthetic routes, the physical properties and also the applications of three commercially available biodegradable materials: Polylactic acid (PLA), Poly(Lactic--Glycolic Acid) (PLGA), and Poly(3-hydroxybutyrate) (P3HB), all of three easily accessible via ROP. In this framework, understanding the origin of enantioselectivity and the factors that determine it is then crucial for the development of materials with suitable thermal and mechanical properties.

摘要

由烯烃过渡金属（TM）聚合催化得到的聚合物材料的可回收性比例较低，这增加了人们对用更环保、具有可靠物理和机械性能的材料替代它们的兴趣。在已知的各种可生物降解聚合物中，通过环状酯的开环聚合（ROP）生产的线性脂肪族聚酯占有突出地位。聚合物的性质高度依赖于大分子的微观结构，立体选择性的控制对于提供具有精确和微调性质的材料是必要的。在这篇综述中，我们旨在概述三种商业上可获得的可生物降解材料的主要合成途径、物理性质和应用：聚乳酸（PLA）、聚（乳酸-乙交酯）（PLGA）和聚（3-羟基丁酸酯）（P3HB），这三种材料都可通过 ROP 轻松获得。在这一框架内，了解对映选择性的起源以及决定对映选择性的因素对于开发具有合适热和机械性能的材料至关重要。

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