Ambrosino N, Pacini F, Paggiaro P L, Martino E, Contini V, Turini L, Tarchi M, Vitti P, Bramanti M, Pinchera A
J Endocrinol Invest. 1985 Dec;8(6):533-6. doi: 10.1007/BF03348555.
Alveolar hypoventilation is known to occur in myxedema. Reduction of hypercapnic ventilatory drive has not been reported, up to now, in patients with short-term hypothyroidism. Eleven patients with short-term hypothyroidism, before and after L-triiodothyronine (L-T3) replacement therapy, and 10 normal controls were studied. Hypercapnic ventilatory drive was assessed by the evaluation of the relation between the response of ventilation and mean expiratory flow to CO2 rebreathing and by the evaluation of ventilation and mean expiratory flow at a fixed level of carbon dioxide. In patients with short-term hypothyroidism these parameters were reduced as compared with normal controls and returned to normal after L-T3 replacement. We conclude that hypercapnic ventilatory drive is blunted by short-term hypothyroidism and normalizes following replacement therapy.
已知黏液性水肿会发生肺泡通气不足。到目前为止，短期甲状腺功能减退患者尚未有高碳酸血症通气驱动降低的报道。对11例短期甲状腺功能减退患者在左甲状腺素（L-T3）替代治疗前后以及10名正常对照者进行了研究。通过评估通气反应与平均呼气流量对二氧化碳再呼吸的关系以及在固定二氧化碳水平下评估通气和平均呼气流量来评估高碳酸血症通气驱动。与正常对照相比，短期甲状腺功能减退患者的这些参数降低，L-T3替代治疗后恢复正常。我们得出结论，短期甲状腺功能减退会使高碳酸血症通气驱动减弱，替代治疗后恢复正常。
