Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.
Student's Scientific Association at the Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.
Int J Mol Sci. 2024 Feb 2;25(3):1829. doi: 10.3390/ijms25031829.
Gestational diabetes mellitus (GDM) is considered one of the most common diseases that occur during pregnancy. In addition to increasing the risk of numerous complications throughout gestation, it is also believed to have a long-term potential to impact the risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular disease for the mother and her offspring. While there are clear guidelines for healthy weight gain in pregnancy depending on pre-pregnancy BMI, as well as dietary and training recommendations to achieve this, an increasing number of women are experiencing excessive gestational weight gain (EGWG). Such patients have a higher risk of developing GDM and gestational hypertension, as well as requiring caesarian delivery. Dipeptidyl peptidase-4 (DPP-4) is a glycoprotein that seems to play an important role in glucose metabolism, and inhibition of its activity positively affects glucose regulation. The aim of our study was to compare DPP-4 concentrations in patients with GDM and EGWG with healthy women. DPP-4 levels were assessed in serum and urine samples collected on the day of delivery. The bioelectrical impedance analysis (BIA) method was also used to analyze the body composition of patients on the second day of the postpartum period. DPP-4 serum concentrations were significantly higher in patients in the GDM and EGWG groups compared to healthy women. Urinary DPP-4 concentrations were significantly higher in the control and GDM groups than in the EGWG group. Serum DPP-4 levels were positively correlated with BMI measured before pregnancy, on the delivery day, and in the early postpartum period, among other factors. According to our knowledge, this is the first study to determine DPP-4 levels in EGWG patients. DPP-4 may be related to the occurrence of GDM and EGWG; however, this requires further research.
妊娠期糖尿病（GDM）被认为是妊娠期间最常见的疾病之一。除了增加整个孕期多种并发症的风险外，它还被认为对母亲及其后代患 2 型糖尿病（T2DM）和心血管疾病的风险有长期潜在影响。虽然有明确的妊娠期健康增重指南，具体取决于孕前 BMI 以及实现这一目标的饮食和训练建议，但越来越多的女性经历了过度妊娠期体重增加（EGWG）。此类患者患 GDM 和妊娠高血压的风险更高，并且需要剖腹产。二肽基肽酶-4（DPP-4）是一种糖蛋白，似乎在葡萄糖代谢中发挥重要作用，其活性的抑制对葡萄糖调节有积极影响。我们的研究目的是比较 GDM 和 EGWG 患者与健康女性的 DPP-4 浓度。在分娩当天采集血清和尿液样本评估 DPP-4 水平。还使用生物电阻抗分析（BIA）方法分析产后第二天患者的身体成分。与健康女性相比，GDM 和 EGWG 组患者的血清 DPP-4 浓度明显更高。对照组和 GDM 组的尿 DPP-4 浓度明显高于 EGWG 组。血清 DPP-4 水平与孕前、分娩当天和产后早期的 BMI 呈正相关，还有其他因素。据我们所知，这是首次确定 EGWG 患者 DPP-4 水平的研究。DPP-4 可能与 GDM 和 EGWG 的发生有关；然而，这需要进一步的研究。
