前列腺癌患者的血清脯氨酰肽酶活性、氧化应激及抗氧化酶水平

Serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with prostate cancer.

作者信息

Kaba Mehmet, Pirincci Necip, Demir Halit, Verep Samed

机构信息

Department of Urology, Private Yuzyil Gebze Hospital, Kocaeli, Turkey.

Department of Urology, Fırat University Medical Faculty, Elazığ, Turkey.

出版信息

Urol Oncol. 2024 Apr;42(4):116.e9-116.e15. doi: 10.1016/j.urolonc.2024.01.007. Epub 2024 Feb 9.

DOI:10.1016/j.urolonc.2024.01.007

PMID:38341363

Abstract

OBJECTIVES

We aimed to identify serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with prostate cancers and to evaluate their relationships with each other.

MATERIALS AND METHODS

A total of 34 male patients with prostate cancer and with a mean age of 64.2 ± 4.4 were included in the study. The control group comprising 36 male patients (mean age 61.2 ± 3.4) was randomly selected among the volunteers. Serum samples for measurement of superoxide dismutase (SOD), glutathione peroxidase (GPx), Catalase (CAT), malondialdehyde (MDA), glutathione (GSH), and prolidase levels were kept at -20°C until they were used.

RESULTS

Serum prolidase activity and MDA levels were significantly higher in prostate cancer patients than in controls (all, P < 0.05), while SOD, GPx, and CAT levels were significantly lower (P < 0.05).

CONCLUSION

Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in prostate cancer.

摘要

目的

我们旨在确定前列腺癌患者的血清脯氨酰二肽氨基肽酶活性、氧化应激和抗氧化酶水平，并评估它们之间的相互关系。

材料与方法

本研究共纳入34例男性前列腺癌患者，平均年龄64.2±4.4岁。对照组由36例男性患者（平均年龄61.2±3.4岁）组成，从志愿者中随机选取。用于测量超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）、过氧化氢酶（CAT）、丙二醛（MDA）、谷胱甘肽（GSH）和脯氨酰二肽氨基肽酶水平的血清样本在使用前保存在-20°C。