Hanada S, Ikeuchi M, Oshima T, Nakaya T, Yagami Y, Yamada Y, Hayashi Y, Takagi T, Ishimaru T, Kitamura T
Jpn J Antibiot. 1985 Dec;38(12):3609-18.
Aztreonam (AZT), a new monocyclic beta-lactam antibiotic was studied on clinical efficacy for infectious disease in gynecological field. At about 80 minutes following intravenous injection of 1 g dose of AZT, it penetrated well into internal genital organs at therapeutic levels. Moreover it transferred very fast and enough into intrapelvic dead space exudate, and its level was kept still as high at 12 hours after administration. AZT was given to 20 women affected with gynecological infectious disease. The outcome of AZT therapy was as follows: effective in 5 out of 6 patients (83.3%) administered intravenously and in all of 14 patients (100%) received intramuscularly. Notable adverse effects or abnormal laboratory findings were not observed except 1 case of diarrhea and 2 cases of transient and slight elevation of serum CPK and transaminases. Based on these results, we may conclude that AZT is a highly effective and a very safe antibiotic for the treatment of infectious disease in gynecological field.
氨曲南（AZT）是一种新型单环β-内酰胺类抗生素，我们对其在妇科领域治疗传染病的临床疗效进行了研究。静脉注射1g剂量的AZT约80分钟后，它能以治疗浓度很好地渗透到内生殖器器官。此外，它能非常快速且充分地转移到盆腔死腔渗出液中，给药后12小时其浓度仍保持在较高水平。对20名患有妇科传染病的女性使用了AZT。AZT治疗的结果如下：静脉给药的6名患者中有5名（83.3%）有效，肌肉注射的14名患者全部（100%）有效。除1例腹泻以及2例血清肌酸磷酸激酶（CPK）和转氨酶短暂轻微升高外，未观察到明显的不良反应或异常实验室检查结果。基于这些结果，我们可以得出结论，氨曲南是治疗妇科领域传染病的一种高效且非常安全的抗生素。
