Horii T, Ikeda M, Shiota M, Watanabe Y, Noda K
Jpn J Antibiot. 1985 Dec;38(12):3660-5.
Fundamental and clinical studies were performed on aztreonam (AZT), a new antibiotic with single beta-lactam ring, with the following results. Following intravenous drip infusion of 1 g, transfer of AZT to the internal genital organs was found to be good. Transfer of AZT to exudate of pelvic dead space was also good. AZT was given to 6 cases, who had gynecological or obstetrical infectious disease. AZT was effective in the 5 cases out of 6, although it showed high MIC against bacteria isolated from the effective cases. The above results demonstrated that AZT was a safe and effective drug.
对新型单β-内酰胺环抗生素氨曲南（AZT）进行了基础和临床研究，结果如下。静脉滴注1克后，发现氨曲南向生殖内器官的转移良好。氨曲南向盆腔死腔渗出液的转移也良好。对6例患有妇产科传染病的患者使用了氨曲南。6例中有5例有效，尽管对有效病例分离出的细菌显示出高最低抑菌浓度（MIC）。上述结果表明氨曲南是一种安全有效的药物。
