Department of Social Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua Humaitá 1680, Araraquara, SP, CEP 14801-903, Brazil.
Department of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, SP, Brazil.
Photochem Photobiol Sci. 2024 Feb;23(2):387-394. doi: 10.1007/s43630-023-00523-0. Epub 2024 Feb 11.
This is a protocol for an overview to summarize the findings of Systematic Reviews (SR) dealing with Photodynamic Inactivation (PDI) for control of oral diseases. Specific variables of oral infectious will be considered as outcomes, according to dental specialty. Cochrane Database of Systematic Reviews (CDSR), MEDLINE, LILACS, Embase, and Epistemonikos will be searched, as well as reference lists. A search strategy was developed for each database using only terms related to the intervention (PDI) aiming to maximize sensitivity. After checking for duplicate entries, selection of reviews will be performed in a two-stage technique: two authors will independently screening titles and abstracts, and then full texts will be assessed for inclusion/exclusion criteria. Any disagreement will be resolved through discussion and/or consultation with a third reviewer. Data will be extracted following the recommendations in Chapter V of Cochrane Handbook and using an electronic pre-specified form. The evaluation of the methodological quality and risk of bias (RoB) of the SR included will be carried out using the AMSTAR 2 and ROBIS. Narrative summaries of relevant results from the individual SR will be carried out and displayed in tables and figures. A specific summary will focus on PDI parameters and study designs, such as the type and concentration of photosensitizer, pre-irradiation time, irradiation dosimetry, and infection or microbiological models, to identify the PDI protocols with clinical potential. We will summarize the quantitative results of the SRs narratively.
这是一份综述协议，旨在总结关于光动力灭活（PDI）控制口腔疾病的系统评价（SR）的发现。根据牙科专业，将考虑口腔感染的特定变量作为结果。 Cochrane 系统评价数据库（CDSR）、MEDLINE、LILACS、Embase 和 Epistemonikos 将被搜索，并查阅参考文献列表。为每个数据库制定了一项搜索策略，仅使用与干预措施（PDI）相关的术语，旨在最大限度地提高敏感性。在检查重复条目后，将采用两阶段技术对综述进行选择：两名作者将独立筛选标题和摘要，然后评估全文是否符合纳入/排除标准。任何分歧将通过讨论和/或咨询第三位审稿人来解决。将按照 Cochrane 手册第五章的建议并使用电子预先指定的表格提取数据。将使用 AMSTAR 2 和 ROBIS 对纳入的 SR 的方法学质量和偏倚风险（RoB）进行评估。将对来自各个 SR 的相关结果进行叙述性总结，并以表格和图形的形式展示。一个专门的总结将重点关注 PDI 参数和研究设计，例如光敏剂的类型和浓度、预辐照时间、辐照剂量以及感染或微生物模型，以确定具有临床潜力的 PDI 方案。我们将对 SR 的定量结果进行叙述性总结。
