Xu Hui, Yu Shenglong, Lin Chunxi, Dong Dingjun, Xiao Jianbo, Ye Yanbin, Wang Mingfu
Institute for Advanced Study, Shenzhen University, Shenzhen, 508060, PR China.
Department of Cardiovascular, Panyu Central Hospital, Guangzhou, 511400, PR China.
Phytomedicine. 2024 Apr;126:155409. doi: 10.1016/j.phymed.2024.155409. Epub 2024 Feb 2.
Flavonoids are extensively present in fruits, vegetables, grains, and medicinal plants. Myocardial ischemia and reperfusion (MI/R) comprise a sequence of detrimental incidents following myocardial ischemia. Research indicates that flavonoids have the potential to act as cardioprotective agents against MI/R injuries. Several specific flavonoids, e.g., luteolin, hesperidin, quercetin, kaempferol, and puerarin, have demonstrated cardioprotective activities in animal models.
The objective of this review is to identify the cardioprotective flavonoids, investigate their mechanisms of action, and explore their application in myocardial ischemia.
A search of PubMed database and Google Scholar was conducted using keywords "myocardial ischemia" and "flavonoids". Studies published within the last 10 years reporting on the cardioprotective effects of natural flavonoids on animal models were analyzed.
A total of 55 natural flavonoids were identified and discussed within this review. It can be summarized that flavonoids regulate the following main strategies: antioxidation, anti-inflammation, calcium modulation, mitochondrial protection, ER stress inhibition, anti-apoptosis, ferroptosis inhibition, autophagy modulation, and inhibition of adverse cardiac remodeling. Additionally, the number and position of OH, 3'4'-catechol, C2=C3, and C4=O may play a significant role in the cardioprotective activity of flavonoids.
This review serves as a reference for designing a daily diet to prevent or reduce damages following ischemia and screening of flavonoids for clinical application.
黄酮类化合物广泛存在于水果、蔬菜、谷物和药用植物中。心肌缺血再灌注（MI/R）是心肌缺血后一系列有害事件。研究表明，黄酮类化合物有潜力作为抗MI/R损伤的心脏保护剂。几种特定的黄酮类化合物，如木犀草素、橙皮苷、槲皮素、山奈酚和葛根素，已在动物模型中显示出心脏保护活性。
本综述的目的是确定具有心脏保护作用的黄酮类化合物，研究其作用机制，并探索它们在心肌缺血中的应用。
使用关键词“心肌缺血”和“黄酮类化合物”在PubMed数据库和谷歌学术上进行检索。分析了过去10年内发表的关于天然黄酮类化合物对动物模型心脏保护作用的研究。
本综述共鉴定并讨论了55种天然黄酮类化合物。可以总结出，黄酮类化合物主要通过以下策略发挥作用：抗氧化、抗炎、钙调节、线粒体保护、内质网应激抑制、抗凋亡、铁死亡抑制、自噬调节以及抑制不良心脏重塑。此外，OH、3'4'-儿茶酚、C2=C3和C4=O的数量和位置可能在黄酮类化合物的心脏保护活性中起重要作用。
本综述可为设计预防或减少缺血后损伤的日常饮食以及筛选临床应用的黄酮类化合物提供参考。
