Laboratory of Development and Drug Technologies, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal.
Laboratory of Development and Drug Technologies, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal; University of Coimbra, LAQV-REQUIMTE, Department of Pharmaceutical Technology, Faculty of Pharmacy, Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal.
Adv Drug Deliv Rev. 2024 Apr;207:115197. doi: 10.1016/j.addr.2024.115197. Epub 2024 Feb 9.
Skin cancer is a heterogeneous disease that can be divided into two main groups, melanoma and nonmelanoma skin cancers. Conventional therapies for skin cancer have numerous systemic side effects and a high recurrence rate. Topical treatment is an alternative approach, but drug permeability remains a challenge. Therefore, nanocarriers appear as important nanotechnology tools that reduces both the side effects and improves clinical outcomes. This is why they are attracting growing interest. In this review, scientific articles on the use of nanocarriers for the topical treatment of skin cancer were collected. Despite the promising results of the presented nanocarriers and considering that some of them are already on the market, there is an urgent need for investment in the development of manufacturing methods, as well as of suitable toxicological and regulatory evaluations, since the conventional methods currently used to develop these nanocarriers-based products are more time-consuming and expensive than conventional products.
皮肤癌是一种异质性疾病，可分为黑色素瘤和非黑色素瘤皮肤癌两类。传统的皮肤癌治疗方法有许多全身性副作用和高复发率。局部治疗是一种替代方法，但药物渗透性仍然是一个挑战。因此，纳米载体作为重要的纳米技术工具，减少了副作用，提高了临床疗效，引起了越来越多的关注。在这篇综述中，收集了关于纳米载体用于皮肤癌局部治疗的科学文章。尽管所提出的纳米载体有很有前景的结果，并且考虑到其中一些已经在市场上，但是迫切需要投资于制造方法的开发，以及适当的毒理学和监管评估，因为目前用于开发这些基于纳米载体的产品的常规方法比传统产品耗时更长，成本更高。
