Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas 13083-871, SP, Brazil.
Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Molecules. 2023 Feb 2;28(3):1449. doi: 10.3390/molecules28031449.
Achieving the best possible outcome for the therapy is the main goal of a medicine. Therefore, nanocarriers and co-delivery strategies were invented to meet this need, as they can benefit many diseases. This approach was applied specifically for cancer treatment, with some success. However, these strategies may benefit many other clinical issues. Skin is the largest and most exposed organ of the human body, with physiological and psychological properties. Due to its exposition and importance, it is not difficult to understand how many skin diseases may impact on patients' lives, representing an important burden for society. Thus, this review aims to summarize the state of the art in research concerning nanocarriers and co-delivery strategies for topical agents' applications targeting skin diseases. The challenge for the medicine of the future is to deliver the drug with spatial and temporal control. Therefore, the co-encapsulation of drugs and the appropriate form of administration for them are so important and remain as unmet needs.
实现治疗的最佳效果是医学的主要目标。因此，发明了纳米载体和共递药策略来满足这一需求，因为它们可以使许多疾病受益。这种方法特别应用于癌症治疗，并取得了一些成功。然而，这些策略可能对许多其他临床问题也有益处。皮肤是人体最大和最暴露的器官，具有生理和心理特性。由于其暴露性和重要性，不难理解许多皮肤疾病可能会对患者的生活产生影响，给社会带来沉重负担。因此，本综述旨在总结纳米载体和共递药策略在针对皮肤疾病的局部药物应用方面的研究现状。未来医学的挑战是实现药物的时空控制递药。因此，药物的共包封和适当的给药形式非常重要，仍然是未满足的需求。
