Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Clin Genet. 2024 Jun;105(6):630-638. doi: 10.1111/cge.14493. Epub 2024 Feb 11.
Psychiatric genetic counseling (pGC) can improve patient empowerment and self-efficacy. We explored the relationship between pGC and psychiatric hospitalizations, for which no prior data exist. Using Population Data BC (a provincial dataset), we tested two hypotheses: (1) among patients (>18 years) with psychiatric conditions who received pGC between May 2010 and Dec 2016 (N = 387), compared with the year pre-pGC, in the year post-pGC there would be fewer (a) individuals hospitalized and (b) total hospital admissions; and (2) using a matched cohort design, compared with controls (N = 363, matched 1:4 for sex, diagnosis, time since diagnosis, region, and age, and assigned a pseudo pGC index date), the pGC cohort (N = 91) would have (a) more individuals whose number of hospitalizations decreased and (b) fewer hospitalizations post-pGC/pseudo-index. We also explored total days in hospital. Within the pGC cohort, there were fewer hospitalizations post-pGC than pre- pGC (p = 0.011, OR = 1.69), and total days in hospital decreased (1085 to 669). However, when compared to matched controls, the post-pGC/pseudo index change in hospitalizations among pGC cases was not statistically significant, even after controlling for the higher number of hospitalizations prior. pGC may lead to fewer psychiatric hospitalizations and cost savings; further studies exploring this are warranted.
精神科遗传咨询(pGC)可以提高患者的授权和自我效能感。我们探索了 pGC 与精神科住院之间的关系,而这方面尚无先前的数据。我们利用卑诗省人口数据(一个省级数据集),检验了两个假设:(1)在 2010 年 5 月至 2016 年 12 月期间接受过 pGC 的(年龄>18 岁)有精神疾病的患者(N=387)与 pGC 前一年相比,pGC 后一年住院人数会更少(a)和(b)总住院人数;(2)使用匹配队列设计,与对照组(N=363,性别、诊断、诊断后时间、地区和年龄相匹配,1:4,分配了一个虚假 pGC 索引日期)相比,pGC 队列(N=91)(a)有更多的住院人数减少的个体和(b)pGC 后/伪索引后的住院次数更少。我们还探索了住院总天数。在 pGC 队列中,pGC 后住院次数少于 pGC 前(p=0.011,OR=1.69),住院总天数减少(从 1085 天减少到 669 天)。然而,与匹配的对照组相比,即使考虑到先前住院次数较多,pGC 患者 pGC 后/伪索引的住院变化也没有统计学意义。pGC 可能会导致较少的精神科住院和节省成本;需要进一步研究探索这一点。