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成纤维细胞生长因子刺激的肌腱细胞在蝾螈组织培养中与 BMP7 一起具有软骨发生命运。

FGF-stimulated tendon cells embrace a chondrogenic fate with BMP7 in newt tissue culture.

机构信息

Department of Basic Biology, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan.

Laboratory for Regenerative Biology, National Institute for Basic Biology (NIBB), Okazaki, Japan.

出版信息

Dev Growth Differ. 2024 Apr;66(3):182-193. doi: 10.1111/dgd.12913. Epub 2024 Feb 11.

DOI:10.1111/dgd.12913
PMID:38342985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11457504/
Abstract

Newts can regenerate functional elbow joints after amputation at the joint level. Previous studies have suggested the potential contribution of cells from residual tendon tissues to joint cartilage regeneration. A serum-free tissue culture system for tendons was established to explore cell dynamics during joint regeneration. Culturing isolated tendons in this system, stimulated by regeneration-related factors, such as fibroblast growth factor (FGF) and platelet-derived growth factor, led to robust cell migration and proliferation. Moreover, cells proliferating in an FGF-rich environment differentiated into Sox9-positive chondrocytes upon BMP7 introduction. These findings suggest that FGF-stimulated cells from tendons may aid in joint cartilage regeneration during functional elbow joint regeneration in newts.

摘要

蝾螈在关节水平截肢后可以再生功能性肘关节。先前的研究表明，残留肌腱组织中的细胞可能对关节软骨再生有贡献。建立了一种无血清组织培养系统来研究肌腱，以探讨关节再生过程中的细胞动态。在这种系统中培养分离的肌腱，受到成纤维细胞生长因子 (FGF) 和血小板衍生生长因子等再生相关因子的刺激，导致细胞大量迁移和增殖。此外，在富含 FGF 的环境中增殖的细胞在引入 BMP7 后分化为 Sox9 阳性软骨细胞。这些发现表明，FGF 刺激的肌腱细胞可能有助于蝾螈功能性肘关节再生过程中的关节软骨再生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/489bf3154928/DGD-66-182-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/098043c4cdbe/DGD-66-182-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/bef12b9eb449/DGD-66-182-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/1797b01553ae/DGD-66-182-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/7f8c55a6ad49/DGD-66-182-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/bf09df2402ae/DGD-66-182-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/489bf3154928/DGD-66-182-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/098043c4cdbe/DGD-66-182-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/bef12b9eb449/DGD-66-182-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/1797b01553ae/DGD-66-182-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/7f8c55a6ad49/DGD-66-182-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/bf09df2402ae/DGD-66-182-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f434/11457504/489bf3154928/DGD-66-182-g007.jpg

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本文引用的文献

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Induced regeneration of articular cartilage - identification of a dormant regeneration program for a non-regenerative tissue.诱导关节软骨再生——为非再生组织鉴定休眠的再生程序。
Development. 2023 Nov 1;150(21). doi: 10.1242/dev.201894. Epub 2023 Nov 8.
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Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration.在蝾螈肢体再生过程中，发育程序的改变和定向细胞分裂导致了骨骼的大量生成。
Nat Commun. 2022 Nov 14;13(1):6949. doi: 10.1038/s41467-022-34266-w.
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An approach for elucidating dermal fibroblast dedifferentiation in amphibian limb regeneration.
一种阐明两栖动物肢体再生中真皮成纤维细胞去分化的方法。
Zoological Lett. 2022 Apr 28;8(1):6. doi: 10.1186/s40851-022-00190-6.
4
Newt Hoxa13 has an essential and predominant role in digit formation during development and regeneration.蝾螈Hoxa13在发育和再生过程中的指（趾）形成中起着至关重要且主要的作用。
Development. 2022 Mar 1;149(5). doi: 10.1242/dev.200282. Epub 2022 Mar 11.
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Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs.分泌抑制剂驱动非洲爪蟾肢体再生能力的丧失。
Development. 2021 Jun 1;148(11). doi: 10.1242/dev.199158. Epub 2021 Jun 9.
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Identification and Distinction of Tenocytes and Tendon-Derived Stem Cells.肌腱细胞与肌腱衍生干细胞的鉴定与区分
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BMP signaling is essential for sustaining proximo-distal progression in regenerating axolotl limbs.BMP 信号对于维持再生蝾螈肢体的近-远轴进展是必不可少的。
Development. 2020 Jul 31;147(14):dev170829. doi: 10.1242/dev.170829.
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Cell type-specific transcriptome analysis unveils secreted signaling molecule genes expressed in apical epithelial cap during appendage regeneration.细胞类型特异性转录组分析揭示了附肢再生过程中顶端上皮帽中表达的分泌信号分子基因。
Dev Growth Differ. 2019 Dec;61(9):447-456. doi: 10.1111/dgd.12635. Epub 2019 Nov 11.
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Model systems for regeneration: salamanders.再生模型系统：蝾螈。
Development. 2019 Jul 22;146(14):dev167700. doi: 10.1242/dev.167700.
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Dev Biol. 2019 Jul 15;451(2):146-157. doi: 10.1016/j.ydbio.2019.04.008. Epub 2019 Apr 23.